{"id":"W4386033551","doi":"10.1038/s42255-023-00885-w","title":"Mitochondrial function and phenotype are defined by bioenergetics","year":2023,"lang":"en","type":"letter","venue":"Nature Metabolism","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; McGill University","funders":"","keywords":"Bioenergetics; Phenotype; Function (biology); Energy metabolism; Mitochondrion; Biology; Chemistry; Genetics; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001041306,0.0004889821,0.0005039997,0.0001570886,0.000127266,0.00006216589,0.0002432466,0.004844081,0.00009607602],"category_scores_gemma":[0.0003767575,0.0004490841,0.0002006726,0.0002041957,0.0001116628,0.00000387423,0.0001553878,0.002197436,0.0001064942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009803292,"about_ca_system_score_gemma":0.00006344343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001352186,"about_ca_topic_score_gemma":0.00002497596,"domain_scores_codex":[0.9977872,0.0002094749,0.0003131524,0.0009411584,0.0003041962,0.0004448645],"domain_scores_gemma":[0.9988508,0.0000437986,0.0002505116,0.0005883733,0.0001717138,0.00009477612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001204998,0.00001453344,0.00001602774,0.00003732169,0.000112587,0.00001825582,0.000004707561,0.000001216336,0.1183108,0.00007482797,0.881005,0.0002842416],"study_design_scores_gemma":[0.0008066876,0.0001075913,0.0001741522,0.00001295623,0.0002345511,0.0000178835,0.000006483187,0.000002416721,0.004434737,0.0004285468,0.9933136,0.000460462],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.009537131,0.1221445,0.006755518,0.6807888,0.1700736,0.002160033,0.004137725,0.0006921202,0.003710514],"genre_scores_gemma":[0.0006911127,0.003183116,0.001794559,0.8353658,0.07582425,0.0001383006,0.01635693,0.0003630482,0.06628293],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.154577,"threshold_uncertainty_score":0.9997961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007665889765237167,"score_gpt":0.2262777011294287,"score_spread":0.2186118113641916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}