{"id":"W4386035313","doi":"10.1016/j.exphem.2023.08.005","title":"Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice","year":2023,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Cancer Institute; MPN Research Foundation; National Institutes of Health; Leukemia and Lymphoma Society; Canadian Institutes of Health Research; Alvin J. Siteman Cancer Center","keywords":"Haematopoiesis; Myeloid; Biology; Stem cell; Hematopoietic stem cell; JAK2 V617F; Cancer research; Janus kinase 2; Progenitor cell; Cell biology; Mutation; Genetics; Gene; Kinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008033089,0.0001111392,0.00038955,0.000207503,0.00003297483,0.000003843251,0.00002259231,0.00004759797,0.0001201846],"category_scores_gemma":[0.00001123579,0.000102712,0.00002349354,0.0001688246,0.00009779564,0.00004681987,0.00006757345,0.00006828226,0.000008897635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000550134,"about_ca_system_score_gemma":0.00001709683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002901449,"about_ca_topic_score_gemma":0.0003948695,"domain_scores_codex":[0.9992114,0.00003614574,0.0002862756,0.0002166658,0.00007805542,0.0001714058],"domain_scores_gemma":[0.9996687,0.0001460871,0.00004324272,0.00007936369,0.0000109706,0.00005165887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002008887,0.0008014877,0.9520044,0.0002259321,0.00007476543,0.0003518499,0.004742476,0.000001442366,0.0245029,0.0163763,0.0005290986,0.0001884586],"study_design_scores_gemma":[0.005730273,0.0005127763,0.2174177,0.0003758152,0.00002610278,0.0008061134,0.01681799,0.0004966159,0.7570837,0.0001917891,0.0003772542,0.0001638754],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948625,0.003331811,0.000001056071,0.0009900322,0.00004707302,0.0003310784,0.00001166152,0.00001742426,0.0004073494],"genre_scores_gemma":[0.9990411,0.0001993478,0.0004161214,0.0001500073,0.000007451174,0.0001173425,0.00003146198,0.000009759047,0.00002736218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7345867,"threshold_uncertainty_score":0.4188472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04596417111803542,"score_gpt":0.360232791609058,"score_spread":0.3142686204910226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}