{"id":"W4386035677","doi":"10.1093/narcan/zcad043","title":"The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors","year":2023,"lang":"en","type":"article","venue":"NAR Cancer","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"PARP1; Context (archaeology); DNA repair; Genome instability; Poly ADP ribose polymerase; DNA Damage Repair; DNA damage; Biology; Chemistry; Computational biology; DNA; Polymerase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004894044,0.0005707216,0.0008430323,0.0007539371,0.0002690743,0.001094348,0.000495373,0.00107078,0.001569565],"category_scores_gemma":[0.0003968855,0.0002476379,0.000543531,0.00072741,0.0004308328,0.001606998,0.0006494407,0.002107966,0.0008235517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000654749,"about_ca_system_score_gemma":0.0005719005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004327507,"about_ca_topic_score_gemma":0.0006776517,"domain_scores_codex":[0.9997814,0.00004467139,0.00002796437,0.00005020302,0.00005815167,0.00003752779],"domain_scores_gemma":[0.9997731,0.00008603585,0.00004848271,0.000006855508,0.00005872969,0.00002681824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004069938,0.0001892538,0.000834498,0.01878687,0.0001640752,0.001281521,0.000537317,0.002129711,0.05528138,0.03009234,0.04591939,0.8443768],"study_design_scores_gemma":[0.00001832183,0.0005415111,0.001652031,0.001203036,0.0001355977,0.002615158,0.0001667266,0.0006836586,0.00976383,0.005128499,0.978043,0.00004868109],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.001359826,0.9943287,0.00105779,0.001113076,0.0004143837,0.000008245258,0.00002979645,0.00002026074,0.001667901],"genre_scores_gemma":[0.006807523,0.9893377,0.0006734629,0.0006790609,0.0008865519,0.00001587634,0.00006471191,0.000007014125,0.001528107],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001569565,"threshold_uncertainty_score":0.005250752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02331743025849306,"score_gpt":0.3375704797925897,"score_spread":0.3142530495340967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}