{"id":"W4386042284","doi":"10.1016/s2665-9913(23)00120-0","title":"Safety and efficacy of mirikizumab versus secukinumab and placebo in the treatment of moderate-to-severe plaque psoriasis (OASIS-2): a phase 3, multicentre, randomised, double-blind study","year":2023,"lang":"en","type":"article","venue":"The Lancet Rheumatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; Probity Medical Research; University of Toronto","funders":"Eli Lilly and Company","keywords":"Secukinumab; Medicine; Placebo; Psoriasis; Psoriasis Area and Severity Index; Clinical trial; Internal medicine; Plaque psoriasis; Adverse effect; Surgery; Dermatology; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002636423,0.001978334,0.005291281,0.0005643156,0.0005646392,0.001311504,0.001271678,0.002611701,0.005025773],"category_scores_gemma":[0.002088139,0.001273771,0.002674063,0.0004993522,0.001955615,0.0017159,0.0005221975,0.003633274,0.001155464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006918372,"about_ca_system_score_gemma":0.0009630018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006792494,"about_ca_topic_score_gemma":0.0009633229,"domain_scores_codex":[0.9987577,0.0007067816,0.00008323471,0.0001851826,0.00009604041,0.0001709557],"domain_scores_gemma":[0.9987446,0.000432998,0.0002464332,0.000117829,0.0000713867,0.0003866021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9899493,0.00290918,0.000163415,0.0002120745,0.0003710336,0.00001440436,0.00002871458,0.0001081677,0.001820319,0.000030037,0.0001381107,0.004255285],"study_design_scores_gemma":[0.8966991,0.0999316,0.001917939,0.00001959717,0.0003778121,0.00002408572,0.00002015372,0.0003164862,0.0003627345,0.0000974235,0.0002119625,0.00002117529],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921805,0.00411537,0.0004868926,0.0003429052,0.0004848659,0.001106636,0.0003566291,0.0001035646,0.000822695],"genre_scores_gemma":[0.9928216,0.001807711,0.0009009215,0.0005898037,0.0004561522,0.00135913,0.0003986654,0.00003157716,0.001634318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005291281,"threshold_uncertainty_score":0.01681286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05122242741578401,"score_gpt":0.3182541849661377,"score_spread":0.2670317575503537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}