{"id":"W4386042284","doi":"10.1016/s2665-9913(23)00120-0","title":"Safety and efficacy of mirikizumab versus secukinumab and placebo in the treatment of moderate-to-severe plaque psoriasis (OASIS-2): a phase 3, multicentre, randomised, double-blind study","year":2023,"lang":"en","type":"article","venue":"The Lancet Rheumatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; Probity Medical Research; University of Toronto","funders":"Eli Lilly and Company","keywords":"Secukinumab; Medicine; Placebo; Psoriasis; Psoriasis Area and Severity Index; Clinical trial; Internal medicine; Plaque psoriasis; Adverse effect; Surgery; Dermatology; Psoriatic arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006001322,0.0003015893,0.001147197,0.0001904253,0.0001869563,0.00001230296,0.0002860014,0.0001866536,0.00004200122],"category_scores_gemma":[0.00008205627,0.0001742162,0.00009397571,0.0003558844,0.0002270112,0.00004049278,0.0000762737,0.0001269486,0.00006005668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003698304,"about_ca_system_score_gemma":0.00005142166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000467567,"about_ca_topic_score_gemma":0.0009573863,"domain_scores_codex":[0.9976878,0.0008514486,0.0005639796,0.0003896898,0.00006316505,0.0004439749],"domain_scores_gemma":[0.9965748,0.002613563,0.0002144568,0.0005289094,0.00003906718,0.00002918037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.919818,0.002492012,0.008330701,0.00005258063,0.00186426,0.0000381368,0.04067865,0.0001317942,0.0004906218,0.0004639158,0.0002994189,0.02533987],"study_design_scores_gemma":[0.964978,0.002924048,0.01800041,0.00005665049,0.0006797685,0.0001495345,0.008049775,0.00009276745,0.0029293,0.00005360962,0.001814439,0.0002716922],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941279,0.001830301,0.000004157583,0.0006587004,0.0003722793,0.00266124,0.0001420066,0.00003881531,0.0001646571],"genre_scores_gemma":[0.9956517,0.003842585,0.00002244428,0.00001683775,0.00001563952,0.0002781105,0.00008939569,0.00001736045,0.00006595861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04515996,"threshold_uncertainty_score":0.7104332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05122242741578401,"score_gpt":0.3182541849661377,"score_spread":0.2670317575503537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}