{"id":"W4386049997","doi":"10.1101/2023.08.21.554160","title":"UBAP2L drives scaffold assembly of nuclear pore complexes at the intact nuclear envelope","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Société d'Accélération du Transfert de Technologies; Institut National Du Cancer; Sanofi; Centre National de la Recherche Scientifique; French Infrastructure for Integrated Structural Biology; China Scholarship Council; Université de Genève; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche","keywords":"Nuclear pore; Nucleoporin; Biogenesis; Scaffold protein; Cell biology; Nuclear transport; Cytoplasm; Nuclear protein; Function (biology); Chemistry; Biology; Cell nucleus; Transcription factor; Biochemistry; Signal transduction; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017486,0.0002332893,0.0001438991,0.0001527694,0.0002125663,0.0004875454,0.0002367881,0.0003203484,0.001513401],"category_scores_gemma":[0.0001057597,0.0002036272,0.0001341654,0.0001019839,0.0002581373,0.0001759569,0.0004650324,0.00050576,0.00103608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005543135,"about_ca_system_score_gemma":0.0002250231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005920322,"about_ca_topic_score_gemma":0.0006505334,"domain_scores_codex":[0.9998784,0.00002110541,0.00000937993,0.00003666278,0.00003433353,0.00002009855],"domain_scores_gemma":[0.9999049,0.00001168505,0.00001987152,0.00002533791,0.00001053122,0.00002769735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008306305,0.00001672578,0.0001365118,0.00002103025,0.000002107314,0.00007490914,0.00001311674,0.00009115463,0.9980951,0.0004074606,0.0002130835,0.0008457258],"study_design_scores_gemma":[0.00002363773,0.00003916988,0.001424634,0.00000374867,0.000002941268,0.0001334986,0.00002680072,0.002847541,0.9896463,0.0001270817,0.005721338,0.000003393877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818841,0.001317436,0.009733723,0.0004149302,0.00007383555,0.00003085133,0.0007180575,0.0005530352,0.005273882],"genre_scores_gemma":[0.9917668,0.0002553728,0.002304611,0.00008480198,0.000009365347,0.00003179971,0.0005805959,0.00006738422,0.004899364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513401,"threshold_uncertainty_score":0.005062819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275658826041092,"score_gpt":0.2166046321428538,"score_spread":0.2038480438824428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}