{"id":"W4386053964","doi":"10.1101/2023.08.21.554162","title":"DENND6A couples Arl8b to a Rab34/RILP/dynein complex regulating retrograde lysosomal trafficking and autophagy","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada First Research Excellence Fund; Royal Society; Royal Society of Canada; ALS Society of Canada; McGill University","keywords":"Cell biology; Dynein; Rab; Guanine nucleotide exchange factor; Autophagy; GTPase; Lysosome; Biology; Small GTPase; Endosome; Axoplasmic transport; Microtubule; Biochemistry; Signal transduction; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718378,0.0003623124,0.0001901889,0.000267966,0.0002846552,0.0004226283,0.0003620336,0.0003138937,0.002358366],"category_scores_gemma":[0.00008469191,0.0002135937,0.0002211444,0.0001395964,0.0003141784,0.0001732034,0.0003418782,0.0004967168,0.001226221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006500974,"about_ca_system_score_gemma":0.0001874282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000439181,"about_ca_topic_score_gemma":0.000655245,"domain_scores_codex":[0.9998098,0.00003070643,0.00002055015,0.00005587123,0.00005050694,0.00003258791],"domain_scores_gemma":[0.999934,0.000006547561,0.00001910909,0.00000965309,0.000008525642,0.00002213998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001111138,0.00003144486,0.0002632258,0.0000301148,0.000003979271,0.00008076821,0.000005397279,0.00009648213,0.998108,0.0002503566,0.0001250296,0.0008941394],"study_design_scores_gemma":[0.00003843598,0.00006795366,0.003724189,0.000007311234,0.000005650524,0.0003999633,0.00002148539,0.002978661,0.9874687,0.00008624401,0.005196973,0.000004445055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864247,0.001751824,0.005843052,0.0003780677,0.0000796946,0.00004847983,0.001051103,0.0002741955,0.004148816],"genre_scores_gemma":[0.9883348,0.0005209414,0.004591458,0.0001172227,0.00001497838,0.0000467049,0.001318545,0.00004924151,0.005006165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002358366,"threshold_uncertainty_score":0.007889569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02136960885751383,"score_gpt":0.2293931311433993,"score_spread":0.2080235222858854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}