{"id":"W4386055115","doi":"10.1101/2023.08.21.554158","title":"Cell therapy with IL-10-producing group 2 innate lymphoid cells suppresses Graft-versus-Host disease","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; University of Toronto; University Health Network","funders":"Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; Mitacs; Novo Nordisk; Canadian Blood Services","keywords":"Innate lymphoid cell; Immunology; Adoptive cell transfer; Immune system; Nod; CD8; Graft-versus-host disease; CD80; Biology; Cell therapy; Innate immune system; Cell; Stem cell; Cancer research; T cell; Medicine; Cytotoxic T cell; Cell biology; In vivo; CD40","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001953714,0.000570602,0.0003501739,0.0002522918,0.0001221907,0.0003625337,0.0001916265,0.0003108786,0.001919848],"category_scores_gemma":[0.00008068362,0.00008270211,0.0001630617,0.0001162195,0.0003315624,0.0001490345,0.0001372072,0.00113171,0.0004287166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881823,"about_ca_system_score_gemma":0.0002895871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002782704,"about_ca_topic_score_gemma":0.0005455898,"domain_scores_codex":[0.9998438,0.00003714846,0.00001282455,0.00002331661,0.00004293234,0.00003991527],"domain_scores_gemma":[0.9999192,0.00001363373,0.00001632362,0.0000131434,0.0000055391,0.00003217112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007897791,0.0006601111,0.000315024,0.0000822793,0.00001467774,0.00006666282,0.00002590401,0.0003448843,0.99174,0.0002738718,0.0005448704,0.005141973],"study_design_scores_gemma":[0.0004762542,0.005468458,0.002482371,0.00001863718,0.00003210232,0.0003100917,0.00003772901,0.002466513,0.9786798,0.0001259005,0.009895009,0.000007232215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925752,0.00144139,0.00223133,0.0002172963,0.0001713845,0.00009937039,0.0005088392,0.0002490678,0.002506209],"genre_scores_gemma":[0.9926665,0.0005114072,0.001772802,0.0001309757,0.00005572391,0.0001649495,0.000574369,0.0000267007,0.004096507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001919848,"threshold_uncertainty_score":0.00642252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881627759709198,"score_gpt":0.206300574783537,"score_spread":0.187484297186445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}