{"id":"W4386055115","doi":"10.1101/2023.08.21.554158","title":"Cell therapy with IL-10-producing group 2 innate lymphoid cells suppresses Graft-versus-Host disease","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; University of Toronto; University Health Network","funders":"Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; Mitacs; Novo Nordisk; Canadian Blood Services","keywords":"Innate lymphoid cell; Immunology; Adoptive cell transfer; Immune system; Nod; CD8; Graft-versus-host disease; CD80; Biology; Cell therapy; Innate immune system; Cell; Stem cell; Cancer research; T cell; Medicine; Cytotoxic T cell; Cell biology; In vivo; CD40","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006614767,0.001265052,0.001071332,0.0004947119,0.0005941649,0.0002360009,0.001262337,0.001003139,0.0002833184],"category_scores_gemma":[0.0001898008,0.001167567,0.0002997347,0.0007965888,0.0005090901,0.0002751953,0.0008274551,0.001227265,0.001808768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002793741,"about_ca_system_score_gemma":0.001285596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000270663,"about_ca_topic_score_gemma":0.00001435904,"domain_scores_codex":[0.9947929,0.0004543937,0.0007631102,0.002315197,0.0002414707,0.00143293],"domain_scores_gemma":[0.9955931,0.0002455747,0.000652798,0.002602462,0.0006382923,0.0002677761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00170141,0.0005185984,0.002607993,0.0006684202,0.0006417991,0.0002045078,0.00007967799,0.00006200714,0.9856587,0.0001070688,0.007747933,0.000001856817],"study_design_scores_gemma":[0.004099317,0.0003786235,0.02018378,0.0004580093,0.0002894644,6.038075e-8,0.00001993059,0.000008118775,0.8560778,0.000002372515,0.1168445,0.001638035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715974,0.005708989,0.0001907383,0.0001361865,0.007547842,0.001432628,0.01186002,0.00147735,0.00004880192],"genre_scores_gemma":[0.993759,0.003872605,0.0004121007,0.0002090261,0.00054529,0.000429221,0.00002997682,0.0004027624,0.0003400391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1295809,"threshold_uncertainty_score":0.9990774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881627759709198,"score_gpt":0.206300574783537,"score_spread":0.187484297186445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}