{"id":"W4386055544","doi":"10.21203/rs.3.rs-3254016/v1","title":"Effect of olanzapine exposure on relapse and brain structure in patients with major depressive disorder with psychotic features","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Treatment of Major Depression","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Health Resources and Services Administration; Canadian Institutes of Health Research; Centre for Addiction and Mental Health Foundation; Fondation Brain Canada; University of Toronto; Allergan; National Institutes of Health; Sage Therapeutics; GlaxoSmithKline; Physicians' Services Incorporated Foundation; Bristol-Myers Squibb; Eli Lilly and Company; Patient-Centered Outcomes Research Institute; National Institute of Mental Health; Ontario Brain Institute; Alzheimer's Association","keywords":"Olanzapine; Depressive symptoms; Major depressive disorder; Psychology; Schizophrenia (object-oriented programming); Clinical psychology; Psychiatry; Medicine; Mood; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510192,0.0003817696,0.0007469029,0.0001609621,0.0002052445,0.0003711733,0.0002018383,0.0003732071,0.001311988],"category_scores_gemma":[0.001033293,0.0001327295,0.0004836195,0.0001310244,0.0002022339,0.000264641,0.0002285513,0.0006862686,0.0001372512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004271102,"about_ca_system_score_gemma":0.0003758662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002605794,"about_ca_topic_score_gemma":0.004675956,"domain_scores_codex":[0.99989,0.00004376054,0.000008935596,0.00001597456,0.00001306965,0.00002818775],"domain_scores_gemma":[0.9997056,0.00006791506,0.00005214961,0.00001683573,0.00001510663,0.0001422735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6960372,0.007942506,0.145512,0.0002936684,0.002061941,0.001389507,0.0003801174,0.0008482431,0.03421063,0.0001310667,0.001230786,0.1099625],"study_design_scores_gemma":[0.01889921,0.08460973,0.8885928,0.00004797256,0.001056756,0.0009924999,0.0003775797,0.001602822,0.002681518,0.0003196837,0.0007608037,0.00005877457],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993432,0.0002163529,0.00001762738,0.0000626935,0.00001834403,0.00001065869,0.00004916197,0.000007875606,0.0002739909],"genre_scores_gemma":[0.999369,0.0001428431,0.00004113223,0.00005169184,0.00001741509,0.00001047936,0.0000917697,0.00000179261,0.0002739257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002605794,"threshold_uncertainty_score":0.005181253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01381566980266426,"score_gpt":0.3454995973496938,"score_spread":0.3316839275470296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}