{"id":"W4386055752","doi":"10.21203/rs.3.rs-3211292/v1","title":"Prospective Phase II Trial of Preoperative Hypofractionated Proton Therapy for Extremity and Truncal Soft Tissue Sarcoma: the PRONTO Study Rationale and Design","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johns Hopkins University","keywords":"Medicine; Soft tissue sarcoma; Sarcoma; Soft tissue; Prospective cohort study; Surgery; Radiation therapy; Clinical trial; Internal medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007304143,0.00317433,0.002812325,0.0005170787,0.0007898874,0.001789662,0.001771866,0.002892116,0.01219825],"category_scores_gemma":[0.006158106,0.001129494,0.002406406,0.0006756117,0.001804608,0.00203254,0.001011512,0.003117566,0.001964419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008315124,"about_ca_system_score_gemma":0.002492936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005094405,"about_ca_topic_score_gemma":0.0009748914,"domain_scores_codex":[0.9959034,0.002852795,0.0002018828,0.0005095853,0.0002570501,0.0002754071],"domain_scores_gemma":[0.9975523,0.0008308849,0.0005498857,0.0003135976,0.0002046446,0.0005486469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.960189,0.01090839,0.00321392,0.002145641,0.00178539,0.0001917796,0.0001315499,0.0009824703,0.004056679,0.0009579974,0.00310386,0.01233326],"study_design_scores_gemma":[0.9094495,0.07974958,0.001953024,0.0001042338,0.0009278474,0.0001172259,0.00004994352,0.0006940431,0.0007757762,0.0009239636,0.005222005,0.00003290541],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.7833514,0.009745182,0.006848001,0.005715515,0.003004701,0.1660541,0.008818129,0.0003477514,0.01611516],"genre_scores_gemma":[0.7710535,0.003674581,0.01003522,0.008846947,0.001995611,0.1842995,0.005396678,0.00006950477,0.01462833],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01219825,"threshold_uncertainty_score":0.04080719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2071801877233179,"score_gpt":0.4754142035378695,"score_spread":0.2682340158145516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}