{"id":"W4386055832","doi":"10.1021/acsinfecdis.3c00113","title":"Potent Antifungal Activity of Penta-<i>O</i>-galloyl-β-<scp>d</scp>-Glucose against Drug-Resistant <i>Candida albicans</i>, <i>Candida auris</i>, and Other Non-<i>albicans Candida</i> Species","year":2023,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University; University of Toronto","funders":"National Center for Complementary and Integrative Health; Canadian Institutes of Health Research; National Institutes of Health; Canadian Institute for Advanced Research","keywords":"Candida albicans; Candida auris; Microbiology; Corpus albicans; Biology; Antifungal drug; Cytotoxicity; Multiple drug resistance; Minimum inhibitory concentration; Drug resistance; In vitro; Antimicrobial; Antifungal; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005337935,0.0008110575,0.001424978,0.0004619413,0.000568148,0.0001441156,0.0003338675,0.000246542,0.000142512],"category_scores_gemma":[0.0008987702,0.0007220132,0.0005735992,0.001278624,0.001040289,0.0003491983,0.0003089827,0.0005727645,0.00008361899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003390675,"about_ca_system_score_gemma":0.0007325439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002314322,"about_ca_topic_score_gemma":0.003035446,"domain_scores_codex":[0.9952169,0.0002505054,0.0008799302,0.001241524,0.001197415,0.001213707],"domain_scores_gemma":[0.9961289,0.0009468472,0.0004829607,0.001200962,0.0003397903,0.0009005347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006570841,0.001301532,0.8511912,0.0008722713,0.000574925,0.0002941042,0.0006888576,0.00003183382,0.1124974,0.0001298423,0.03028273,0.001478241],"study_design_scores_gemma":[0.003938783,0.0006715714,0.9259059,0.0004926669,0.0009628181,0.00003181264,0.001252735,0.00008692485,0.04050044,0.0002294827,0.02542344,0.0005034104],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806574,0.001697175,0.00006009081,0.0002655139,0.000465258,0.001285076,0.001537411,0.0005066051,0.01352547],"genre_scores_gemma":[0.9902659,0.002610908,0.00001869335,0.001247906,0.000397208,0.000124261,0.0001623062,0.0001466717,0.005026117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07471475,"threshold_uncertainty_score":0.9995231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01051548115868922,"score_gpt":0.2499230348516339,"score_spread":0.2394075536929446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}