{"id":"W4386056621","doi":"10.1016/j.canlet.2023.216363","title":"Photodynamic augmentation of oncolytic virus therapy for central nervous system malignancies","year":2023,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill Genome Centre; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Neurological Disorders and Stroke; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; National Cancer Institute; National Institutes of Health; Meningioma Mommas; Massachusetts General Hospital","keywords":"Oncolytic virus; Photodynamic therapy; Tumor microenvironment; Cancer research; Virotherapy; In vivo; Brain tumor; Medicine; Immune system; Cancer; Pathology; Biology; Immunology; Chemistry; Tumor cells; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001677519,0.0001677616,0.0001614082,0.0002030834,0.000165932,0.0004355438,0.0002842799,0.0003423622,0.001711594],"category_scores_gemma":[0.0001434162,0.0001009663,0.0001865561,0.0001886335,0.0002495359,0.0003217428,0.000184518,0.000453925,0.0002394237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005473428,"about_ca_system_score_gemma":0.0003172189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006461377,"about_ca_topic_score_gemma":0.0007940529,"domain_scores_codex":[0.999926,0.00001249078,0.00000425087,0.00001295943,0.00002733895,0.00001700724],"domain_scores_gemma":[0.9999583,0.00001469154,0.000007524409,0.000009289792,0.00000560124,0.00000459462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000348658,0.00007477498,0.0002394105,0.0001434154,0.00001197161,0.0001794873,0.00003830604,0.0005394522,0.9729636,0.002283056,0.0007450211,0.0224328],"study_design_scores_gemma":[0.00003677853,0.0002944291,0.001393161,0.000009320696,0.00002190497,0.0006996176,0.00002323678,0.001893412,0.9789239,0.0004204815,0.01627631,0.000007381038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9348854,0.02616063,0.01703166,0.001702952,0.0005310561,0.0001365841,0.0002228958,0.0003760193,0.0189528],"genre_scores_gemma":[0.9851815,0.004532402,0.003622146,0.0001176499,0.00006712269,0.00004591592,0.00009167499,0.00004322341,0.006298306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001711594,"threshold_uncertainty_score":0.00572592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123218931730549,"score_gpt":0.3134765973742822,"score_spread":0.2922444080569767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}