{"id":"W4386056621","doi":"10.1016/j.canlet.2023.216363","title":"Photodynamic augmentation of oncolytic virus therapy for central nervous system malignancies","year":2023,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill Genome Centre; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Neurological Disorders and Stroke; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; National Cancer Institute; National Institutes of Health; Meningioma Mommas; Massachusetts General Hospital","keywords":"Oncolytic virus; Photodynamic therapy; Tumor microenvironment; Cancer research; Virotherapy; In vivo; Brain tumor; Medicine; Immune system; Cancer; Pathology; Biology; Immunology; Chemistry; Tumor cells; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001379158,0.0001114448,0.0001292805,0.00006200656,0.00005573574,0.00001293286,0.000169096,0.00005557999,0.00001338224],"category_scores_gemma":[0.000006492096,0.000107387,0.00009995617,0.0001500697,0.00006581821,0.000003285029,0.00002248952,0.0000365254,0.000006611294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001027115,"about_ca_system_score_gemma":0.0001157397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008966369,"about_ca_topic_score_gemma":0.0001400864,"domain_scores_codex":[0.9990945,0.00004373531,0.0001614475,0.0002344251,0.0001456586,0.0003201707],"domain_scores_gemma":[0.9995981,0.00001427113,0.0000736915,0.0002149774,0.00005119246,0.0000478019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001404564,0.00001240983,0.0001918734,0.00009143155,0.00008685949,0.000002242475,0.0001041758,0.002306172,0.9848028,0.00000610811,0.005552641,0.005438743],"study_design_scores_gemma":[0.001199044,0.0006427126,0.001757203,0.00003153654,0.000009959219,0.000001144785,0.0001049674,0.0006597055,0.992458,0.000003080039,0.003007346,0.0001252971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973289,0.0006326938,0.0004746063,0.0005136183,0.0002847951,0.0005725647,0.000141518,0.00002926132,0.00002198753],"genre_scores_gemma":[0.9975578,0.0005508615,0.00004265822,0.0008433164,0.000216232,0.0004018339,0.0001586922,0.00003389746,0.0001946722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007655224,"threshold_uncertainty_score":0.4379115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123218931730549,"score_gpt":0.3134765973742822,"score_spread":0.2922444080569767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}