{"id":"W4386062467","doi":"10.14740/cmmr10e","title":"Advances in Molecular Perspectives of Tumor-Initiating Cells on Cancer Therapy","year":2023,"lang":"en","type":"article","venue":"Cellular and Molecular Medicine Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Toronto General Hospital","funders":"","keywords":"Cancer stem cell; CD44; Homeobox protein NANOG; Wnt signaling pathway; SOX2; Cancer research; Biology; Cancer; Stem cell; Cancer cell; Tumor initiation; Carcinogenesis; Induced pluripotent stem cell; Cell; Cell biology; Embryonic stem cell; Signal transduction; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001474859,0.0005748062,0.0006939354,0.001259061,0.0003221449,0.001561309,0.0006471367,0.001331456,0.005971334],"category_scores_gemma":[0.0009051597,0.0002121923,0.0005304724,0.0009856556,0.001222085,0.001929373,0.0009327004,0.003250509,0.00238004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00109533,"about_ca_system_score_gemma":0.0009482883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004281276,"about_ca_topic_score_gemma":0.0006867785,"domain_scores_codex":[0.9994392,0.0001664853,0.00003302817,0.00009639554,0.0002028473,0.00006205172],"domain_scores_gemma":[0.9993165,0.0003133521,0.00005474078,0.0000542861,0.0001697353,0.0000913618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0004136728,0.0004256814,0.0009675297,0.00406333,0.00007975021,0.0006937722,0.0004172392,0.0013251,0.06982973,0.1646102,0.03927367,0.7179003],"study_design_scores_gemma":[0.00004968893,0.0005090257,0.001397019,0.000559449,0.0000754935,0.001492977,0.000147275,0.001072777,0.025453,0.03463222,0.9345722,0.0000388787],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.007994658,0.9268269,0.01235107,0.02087804,0.002833017,0.00004723017,0.0001530561,0.0001575686,0.02875852],"genre_scores_gemma":[0.06552551,0.9045396,0.009710184,0.005222407,0.00411209,0.00007858737,0.00021449,0.0000580838,0.01053901],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005971334,"threshold_uncertainty_score":0.01997614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05799747856073888,"score_gpt":0.409307939304332,"score_spread":0.3513104607435931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}