{"id":"W4386068123","doi":"10.3389/fimmu.2023.1222267","title":"Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Syphilis Diagnosis and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Connecticut Children's Medical Center; National Institute of General Medical Sciences; University of Connecticut Health Center","keywords":"Bama; Epitope; Biology; Molecular biology; Monoclonal antibody; Treponema; Phage display; Bacterial outer membrane; Antiserum; Conformational epitope; Antigen; Virology; Immunogenicity; Epitope mapping; Antibody; Microbiology; Biochemistry; Escherichia coli; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445219,0.0004308593,0.0001253323,0.0001783589,0.00008202235,0.0002379835,0.0002429936,0.0002531865,0.0006435568],"category_scores_gemma":[0.00009048138,0.0001133956,0.0001962874,0.0001032084,0.0001106002,0.0001272474,0.0003025955,0.0004137241,0.0002605121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00015744,"about_ca_system_score_gemma":0.00008019316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002512776,"about_ca_topic_score_gemma":0.0003308254,"domain_scores_codex":[0.9998841,0.00001578754,0.000008106706,0.000028201,0.00003311682,0.00003063228],"domain_scores_gemma":[0.9999549,0.000007622501,0.00001217546,0.000006511084,0.000006707308,0.00001208688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002786011,0.00002676619,0.0001290818,0.000009442924,0.000002482285,0.00003504151,0.00000650859,0.00005117519,0.9983277,0.00005915888,0.00001910757,0.001305659],"study_design_scores_gemma":[0.00001059703,0.0003061279,0.002005484,0.000002676981,0.00001134253,0.0003091928,0.000008923476,0.001451341,0.9942814,0.00001960752,0.001589873,0.00000339701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861312,0.0001690635,0.011995,0.00003765774,0.00001302837,0.00004711641,0.0001370389,0.00007338206,0.001396467],"genre_scores_gemma":[0.9854774,0.0001929853,0.01061354,0.00005072647,0.000004091336,0.000036159,0.0005541388,0.00001854129,0.00305238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006435568,"threshold_uncertainty_score":0.00215292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02701163346666683,"score_gpt":0.2787804023842366,"score_spread":0.2517687689175698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}