{"id":"W4386068123","doi":"10.3389/fimmu.2023.1222267","title":"Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Syphilis Diagnosis and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Connecticut Children's Medical Center; National Institute of General Medical Sciences; University of Connecticut Health Center","keywords":"Bama; Epitope; Biology; Molecular biology; Monoclonal antibody; Treponema; Phage display; Bacterial outer membrane; Antiserum; Conformational epitope; Antigen; Virology; Immunogenicity; Epitope mapping; Antibody; Microbiology; Biochemistry; Escherichia coli; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002544452,0.0003287164,0.001108922,0.0006475705,0.00005092744,0.00001013829,0.0001525992,0.000203655,0.00002434917],"category_scores_gemma":[0.0002062031,0.0002546723,0.0001668563,0.0009161882,0.0002257207,0.00008954736,0.00008599132,0.0002460264,0.00001549705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002093113,"about_ca_system_score_gemma":0.0001574969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000313324,"about_ca_topic_score_gemma":0.00009916443,"domain_scores_codex":[0.9979222,0.0002153122,0.0005136972,0.0005605276,0.0002636019,0.0005246136],"domain_scores_gemma":[0.9986133,0.0002273822,0.0002690679,0.0006706162,0.0001158443,0.0001038023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006434362,0.003050594,0.4830842,0.0001127783,0.0014788,0.001828207,0.0007865453,0.0004866533,0.4611157,0.0001013169,0.001374013,0.04014674],"study_design_scores_gemma":[0.004708269,0.00260163,0.7015513,0.0004951959,0.0001913912,0.00002603524,0.0002025978,0.003273929,0.2857324,0.000013754,0.0009427033,0.0002607457],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952074,0.002078982,0.0004529071,0.0005618553,0.0005452199,0.0009491349,0.0001032788,0.00006473849,0.00003650949],"genre_scores_gemma":[0.9934846,0.001816469,0.003769248,0.00004928165,0.00003229454,0.0001699905,0.0001628503,0.00005065844,0.0004645851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2184671,"threshold_uncertainty_score":0.9999905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02701163346666683,"score_gpt":0.2787804023842366,"score_spread":0.2517687689175698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}