{"id":"W4386068166","doi":"10.3389/fimmu.2023.1231916","title":"KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Feldan (Canada); Centre Hospitalier Universitaire Sainte-Justine","funders":"Fondation Charles-Bruneau; Natural Sciences and Engineering Research Council of Canada; CHU Sainte-Justine Foundation; Mitacs; Fonds de Recherche du Québec - Santé; Cole Foundation","keywords":"Cancer research; Cytotoxicity; Interleukin 12; Lymphokine-activated killer cell; Immune system; Interleukin 21; Natural killer cell; Immunotherapy; Cell; Biology; Cancer immunotherapy; Immunology; T cell; Chemistry; In vitro; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299517,0.0004916426,0.0004650681,0.0002896777,0.0001073253,0.000367417,0.0003083334,0.000391532,0.002330268],"category_scores_gemma":[0.000113322,0.0001268,0.000276608,0.0001635484,0.0002469184,0.00023348,0.0001781659,0.0007806702,0.000769279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002869547,"about_ca_system_score_gemma":0.0002333164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003431056,"about_ca_topic_score_gemma":0.0004108243,"domain_scores_codex":[0.9997064,0.00002737926,0.00004682375,0.00006633029,0.00007648663,0.00007645666],"domain_scores_gemma":[0.99984,0.00001871733,0.00006548093,0.00002110685,0.00001108852,0.00004359105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001727747,0.00007015507,0.0001736035,0.00008006667,0.000009118043,0.00004617533,0.000008540192,0.0001710601,0.9965345,0.00007705791,0.0001254144,0.00253153],"study_design_scores_gemma":[0.00003662682,0.000502546,0.002019667,0.00000786829,0.0000294181,0.0003934806,0.00001806578,0.0005974647,0.9927788,0.00003544989,0.003574688,0.000005914771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987008,0.003713306,0.004604709,0.0001920372,0.00008956673,0.0000602292,0.001281512,0.0006857818,0.002364873],"genre_scores_gemma":[0.9936651,0.000930278,0.001308602,0.00005065396,0.00000909655,0.00003708079,0.0008174518,0.00004363821,0.003138118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002330268,"threshold_uncertainty_score":0.007795513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006758467187037404,"score_gpt":0.2159049187111644,"score_spread":0.2091464515241269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}