{"id":"W4386070150","doi":"10.1101/2023.08.21.554083","title":"Multimodal Imaging Investigation of Rich Club Alterations in Alzheimer’s Disease and Mild Cognitive Impairment: Amyloid Deposition, Structural Atrophy, and Functional Activation Differences","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Neuroscience; Disease; Neuroimaging; White matter; Psychology; Diffusion MRI; Grey matter; Pathology; Medicine; Magnetic resonance imaging; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001361728,0.0003533389,0.0004718393,0.00179303,0.0002056479,0.0006820279,0.0002744526,0.0003382017,0.001545185],"category_scores_gemma":[0.002768634,0.0001540232,0.0004499985,0.001080499,0.0002989717,0.0004476533,0.000503908,0.0002463538,0.00009868845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002212046,"about_ca_system_score_gemma":0.0002151668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222105,"about_ca_topic_score_gemma":0.002264212,"domain_scores_codex":[0.9997749,0.00009661238,0.00001893504,0.00005688309,0.0000327693,0.0000198957],"domain_scores_gemma":[0.9990522,0.0003900052,0.0002992596,0.0001106422,0.00007818777,0.00006957242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00266194,0.0003920749,0.8668035,0.001369547,0.005964121,0.001103052,0.0006544326,0.003147331,0.05414357,0.001447243,0.0015357,0.06077755],"study_design_scores_gemma":[0.00005482223,0.0003246355,0.9789128,0.0001260033,0.001638592,0.001082439,0.0003026083,0.006617347,0.005095512,0.004945946,0.0008777372,0.00002155286],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910321,0.003050336,0.003866575,0.0001908528,0.00001543767,0.00002730411,0.000611907,0.00003499987,0.001170521],"genre_scores_gemma":[0.9969188,0.0005587012,0.002025511,0.00003745775,0.00002548336,0.00001968704,0.0002408988,0.000007378274,0.0001661681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179303,"threshold_uncertainty_score":0.007201612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04501461390813247,"score_gpt":0.2864632776217589,"score_spread":0.2414486637136264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}