{"id":"W4386071185","doi":"10.1016/j.celrep.2023.112997","title":"Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Complementary and Integrative Health; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Chiba University; University of California, San Diego; NOMIS Stiftung; National Cancer Institute; National Institutes of Health; Crohn's and Colitis Foundation of America; March of Dimes Foundation; David C. Copley Foundation; Samuel Waxman Cancer Research Foundation","keywords":"Metabolome; Microbiome; Metabolomics; Colorectal cancer; Biology; Bile acid; Ruminococcus; Cancer; Omics; Disease; Cholic acid; Bioinformatics; Computational biology; Internal medicine; Genetics; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006539574,0.000395598,0.0006894792,0.001163869,0.0003317429,0.0008798418,0.0001951664,0.0005139065,0.002009153],"category_scores_gemma":[0.001647738,0.0002292893,0.0007201813,0.001255046,0.0002057709,0.0003198293,0.0009743886,0.0006611128,0.0004158692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002488286,"about_ca_system_score_gemma":0.0002759963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001309782,"about_ca_topic_score_gemma":0.002626523,"domain_scores_codex":[0.9995146,0.0001037687,0.00004386447,0.0001807318,0.00008250025,0.00007458865],"domain_scores_gemma":[0.9989491,0.0001734027,0.0003975384,0.0001476114,0.000148774,0.000183683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003397958,0.0001598066,0.8784985,0.0003702007,0.002319908,0.0002443834,0.0001459139,0.0009781431,0.08169208,0.0002256408,0.001839647,0.03012798],"study_design_scores_gemma":[0.00002829116,0.0003973359,0.9848525,0.00004210496,0.000696459,0.0005973178,0.0001743253,0.001483868,0.007420693,0.0006811282,0.003595054,0.00003093695],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811183,0.003547273,0.002292676,0.0003156278,0.00005358311,0.00002311949,0.01156812,0.0001005779,0.0009808651],"genre_scores_gemma":[0.9889805,0.0009748323,0.00197582,0.000192097,0.00003312918,0.00003092946,0.007056952,0.00003744964,0.0007181902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002009153,"threshold_uncertainty_score":0.006721258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0219227712800128,"score_gpt":0.3181297968698472,"score_spread":0.2962070255898344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}