{"id":"W4386084757","doi":"10.7554/elife.90006","title":"Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Human Islet Research Network; Juvenile Diabetes Research Foundation International; California Institute for Regenerative Medicine","keywords":"Islet; Cell biology; Extracellular matrix; Cell adhesion; Cell adhesion molecule; Integrin; Cell; Biology; Enteroendocrine cell; Chemistry; Endocrine system; Endocrinology; Insulin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001719505,0.0002273965,0.0002122032,0.0002495014,0.0002687843,0.0009373588,0.0002497966,0.0003020226,0.0005555846],"category_scores_gemma":[0.0001874664,0.0002199527,0.0001689204,0.0002005813,0.00029523,0.0003860676,0.0004165834,0.0006663729,0.0003346868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005901848,"about_ca_system_score_gemma":0.0003276355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043209,"about_ca_topic_score_gemma":0.00168459,"domain_scores_codex":[0.999745,0.00002459611,0.00001406225,0.00005731248,0.00006795869,0.00009109023],"domain_scores_gemma":[0.9998322,0.00001540606,0.00006636711,0.00001352109,0.0000245689,0.0000480066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006351551,0.00001341257,0.001117584,0.0000188655,0.000004508954,0.00009519371,0.00002697577,0.0001219068,0.9944529,0.0004190078,0.0001372784,0.003528808],"study_design_scores_gemma":[0.00002284312,0.0001016926,0.06763455,0.00001663082,0.00002980063,0.0003827106,0.0002902992,0.005142489,0.9171734,0.0004692419,0.008718523,0.00001781674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851589,0.00321266,0.007285477,0.0001925873,0.00003750562,0.000015642,0.000248405,0.0001443462,0.003704577],"genre_scores_gemma":[0.9940261,0.001309206,0.001754504,0.00006285083,0.00001036824,0.00001966221,0.0002014763,0.00002830861,0.002587543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001043209,"threshold_uncertainty_score":0.004282176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01898057536132022,"score_gpt":0.2359552158610541,"score_spread":0.2169746404997339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}