{"id":"W4386088828","doi":"10.1126/sciadv.adg6693","title":"A MYCN-independent mechanism mediating secretome reprogramming and metastasis in <i>MYCN</i> -amplified neuroblastoma","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"Stand Up To Cancer; National Cancer Institute; National Institutes of Health; BC Cancer Foundation; Michael Smith Health Research BC; Lotte and John Hecht Memorial Foundation; Canadian Institutes of Health Research; Alex's Lemonade Stand Foundation for Childhood Cancer; Damon Runyon Cancer Research Foundation; American Association for Cancer Research","keywords":"Neuroblastoma; Mechanism (biology); Reprogramming; Metastasis; Cancer research; Biology; Genetics; Cancer; Gene; Cell culture; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006923787,0.0001644137,0.0001406871,0.000150758,0.0001268562,0.0002289649,0.00009775846,0.0001608457,0.0005811761],"category_scores_gemma":[0.00007219601,0.00008086008,0.0001236207,0.00007786531,0.0001740499,0.0001848224,0.0002136858,0.000233684,0.0001756374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002438763,"about_ca_system_score_gemma":0.000132514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007120815,"about_ca_topic_score_gemma":0.001597919,"domain_scores_codex":[0.9999571,0.000004757038,0.000002203764,0.00001121589,0.00001347499,0.0000113449],"domain_scores_gemma":[0.9999658,0.000003751661,0.00001211063,0.000003455451,0.000003797351,0.00001099322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004058777,0.000003555653,0.001289097,0.00001839427,0.000001921251,0.00009996218,0.000014251,0.00003265202,0.9975336,0.0001018773,0.00001707058,0.0008470503],"study_design_scores_gemma":[0.00001451217,0.0001675689,0.1211194,0.00002132589,0.00002114271,0.001772658,0.000177326,0.001892358,0.8697675,0.0003041454,0.004731507,0.00001042516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945246,0.001925558,0.001759254,0.00007481348,0.00001149773,0.00001520349,0.000296159,0.00003103263,0.001361878],"genre_scores_gemma":[0.9959192,0.001109281,0.001325474,0.00003379246,0.000004991533,0.00001384123,0.0003134598,0.000005910297,0.001274183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007120815,"threshold_uncertainty_score":0.001944244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02478320280546596,"score_gpt":0.3358914583046829,"score_spread":0.3111082554992169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}