{"id":"W4386090061","doi":"10.1021/acschembio.3c00319","title":"G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Institut National de la Recherche Scientifique; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Intracellular; Receptor; Chemistry; G protein-coupled receptor; Secretion; Angiotensin II; Functional selectivity; Tyrosine; Cell biology; Peptide; Amino acid; Biochemistry; Small molecule; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003660687,0.0002053444,0.0002557547,0.00008161952,0.00005605497,0.00001703542,0.0001964373,0.0005335588,0.00004544514],"category_scores_gemma":[0.0003188046,0.0001968303,0.0001181284,0.000264446,0.00008729105,0.000003569678,0.0001126861,0.00008688926,0.00003013519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003228205,"about_ca_system_score_gemma":0.000061538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001173101,"about_ca_topic_score_gemma":0.00000644019,"domain_scores_codex":[0.9984905,0.00007428895,0.0003188389,0.0005587557,0.00007184993,0.0004857347],"domain_scores_gemma":[0.999455,0.00003155575,0.00009333351,0.0002415303,0.00008574123,0.00009287499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001898254,0.00003255214,0.0001052677,0.00002339637,0.00002638311,0.000002960912,0.00003711035,0.00001198571,0.9955086,0.000195027,0.00130682,0.002560135],"study_design_scores_gemma":[0.0007158522,0.000334226,0.00002007738,0.00002787176,0.000006870165,0.000004246393,0.00002422211,0.0003270507,0.9667067,0.001247904,0.03034742,0.0002375706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967022,0.0001407154,0.00156995,0.000454357,0.0002053326,0.0007964003,0.00003132303,0.00005204831,0.0000476616],"genre_scores_gemma":[0.9938002,0.00004002581,0.003170379,0.0001172089,0.0003223119,0.0001998826,0.001853413,0.00003970083,0.0004568535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0290406,"threshold_uncertainty_score":0.8026505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01298601774226074,"score_gpt":0.2506338083824487,"score_spread":0.237647790640188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}