{"id":"W4386098421","doi":"10.7554/elife.90333","title":"Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé","keywords":"Neurotrophin; Biology; Endocrinology; Neurotrophic factors; Internal medicine; Brain-derived neurotrophic factor; Hypothalamus; Tropomyosin receptor kinase B; Cell biology; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008830141,0.0003949954,0.0002373636,0.0002728259,0.0001479345,0.000196858,0.0001728143,0.0003237984,0.0007690888],"category_scores_gemma":[0.00009370193,0.0001730212,0.0002281597,0.0001011408,0.0003355655,0.0001183455,0.0002417675,0.0004770972,0.000251296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002165193,"about_ca_system_score_gemma":0.0001659059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000792419,"about_ca_topic_score_gemma":0.001661711,"domain_scores_codex":[0.9999257,0.000009031398,0.000009136045,0.00002026088,0.00001949482,0.00001622902],"domain_scores_gemma":[0.9999262,0.000007647985,0.00003243836,0.000004889765,0.000004395724,0.0000244637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006804643,0.000004198987,0.0005014913,0.00002211682,0.000005700816,0.0001782652,0.00001197121,0.0000480144,0.9980606,0.00008453006,0.00003258393,0.0009824239],"study_design_scores_gemma":[0.00004447803,0.0002287264,0.0427936,0.00002452076,0.00006068195,0.003119451,0.000101118,0.001382454,0.9474597,0.0002620374,0.0045093,0.00001394777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947321,0.001944347,0.001684719,0.0002014034,0.00002283143,0.00000753933,0.0003170152,0.00009873363,0.0009911691],"genre_scores_gemma":[0.9953009,0.001005478,0.001700107,0.00005094165,0.00000707859,0.00001133873,0.0002322964,0.00001793614,0.001673884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000792419,"threshold_uncertainty_score":0.002572834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293177086576072,"score_gpt":0.2357463082734978,"score_spread":0.2228145374077371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}