{"id":"W4386098421","doi":"10.7554/elife.90333","title":"Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé","keywords":"Neurotrophin; Biology; Endocrinology; Neurotrophic factors; Internal medicine; Brain-derived neurotrophic factor; Hypothalamus; Tropomyosin receptor kinase B; Cell biology; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001546791,0.0002579085,0.000214243,0.00009141742,0.0002187761,0.00008303409,0.0001754405,0.0001199728,0.00004149545],"category_scores_gemma":[0.0001791704,0.0002486162,0.0001143504,0.000289811,0.0001174969,0.00001834766,0.0001796343,0.0001078907,0.0000686183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001072395,"about_ca_system_score_gemma":0.0000811596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002229706,"about_ca_topic_score_gemma":0.000002694336,"domain_scores_codex":[0.9982783,0.0001026434,0.0002870607,0.0006947737,0.0002513765,0.0003858798],"domain_scores_gemma":[0.9991487,0.00001856171,0.0001049266,0.0004893811,0.00006800232,0.0001704724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007414333,0.00005829336,0.003504813,0.00007741056,0.00006056045,0.0001236959,0.0000782147,0.0003714683,0.9912919,0.00006276275,0.003063863,0.001232823],"study_design_scores_gemma":[0.001775603,0.0004723335,0.1844678,0.0001164233,0.0001002794,0.0001889946,0.0001110755,0.001752005,0.7930455,0.0003930007,0.01670535,0.0008716198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965509,0.001436705,0.0001364822,0.0009163345,0.0001285084,0.0004427477,0.00004519602,0.0001261733,0.000216999],"genre_scores_gemma":[0.996174,0.0005638412,0.0005388217,0.0002935476,0.0002213843,0.00005879199,0.0001424972,0.0000587897,0.00194836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1982464,"threshold_uncertainty_score":0.9999966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293177086576072,"score_gpt":0.2357463082734978,"score_spread":0.2228145374077371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}