{"id":"W4386098928","doi":"10.26685/urncst.498","title":"Analysis of the Effect of Substrate Stiffness on the Efficacy of Fibroblast Growth Factor 2 and Bone Morphogenetic Protein 4 in Inducing Pro-Regenerative Astrocyte Phenotype: A Research Protocol","year":2023,"lang":"en","type":"article","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Bone morphogenetic protein; Cell biology; Glial fibrillary acidic protein; Extracellular matrix; Bone morphogenetic protein 2; Fibroblast growth factor; Astrocyte; Growth factor; Regenerative medicine; Chemistry; Biology; Stem cell; Immunology; Neuroscience; Biochemistry; In vitro; Central nervous system; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008654378,0.001107446,0.0004529404,0.0004977747,0.0003564035,0.0002715965,0.0004714289,0.0005554839,0.0029348],"category_scores_gemma":[0.0003696064,0.0003558309,0.0006501222,0.0007681933,0.0002699173,0.0002840542,0.0002733479,0.0005151264,0.0006276622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00029023,"about_ca_system_score_gemma":0.0006079183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006172536,"about_ca_topic_score_gemma":0.001326145,"domain_scores_codex":[0.9992958,0.0000947107,0.0001440412,0.0001136145,0.0002724664,0.00007937699],"domain_scores_gemma":[0.9993652,0.0001962766,0.0001261458,0.00008120612,0.0001745255,0.00005664896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007173203,0.00009529423,0.00005618281,0.00008866927,0.000003599685,0.00002814323,0.00002044421,0.00007941716,0.9984924,0.00003080617,0.00002900268,0.001004421],"study_design_scores_gemma":[0.00001904858,0.001124888,0.001218845,0.000009995929,0.00002757933,0.00004624064,0.00002440885,0.0003631739,0.9955551,0.00002818888,0.001571865,0.00001066147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9363981,0.003807329,0.04594838,0.0002100662,0.0001897238,0.003914776,0.002472288,0.0002968163,0.00676252],"genre_scores_gemma":[0.7619361,0.01163835,0.1748436,0.0002062795,0.00008915693,0.01624293,0.007322754,0.0001595447,0.02756132],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.0029348,"threshold_uncertainty_score":0.009817958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07208741744696422,"score_gpt":0.4278176693173753,"score_spread":0.3557302518704111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}