{"id":"W4386100118","doi":"10.1038/s43856-023-00340-7","title":"Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells","year":2023,"lang":"en","type":"article","venue":"Communications Medicine","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; National Research Council Canada","funders":"","keywords":"Chinese hamster ovary cell; Virus-like particle; Virology; Cricetulus; Biology; Antigen; Virus; Glycosylation; Hamster; In vivo; Titer; Antibody; Cell culture; Cell biology; Molecular biology; Recombinant DNA; Immunology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001066631,0.0009379449,0.0006504066,0.0004910223,0.0002091571,0.0004871635,0.0007056631,0.0008739292,0.001334953],"category_scores_gemma":[0.0004362876,0.0001978836,0.0007479371,0.0003618187,0.0003426805,0.0003599605,0.0002286813,0.001306118,0.0004973839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005254849,"about_ca_system_score_gemma":0.0005921653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001145585,"about_ca_topic_score_gemma":0.0009845031,"domain_scores_codex":[0.9996009,0.00008832338,0.00003809418,0.00005805601,0.0001297897,0.00008483711],"domain_scores_gemma":[0.9996024,0.00007892082,0.00008643051,0.00006276121,0.0001045502,0.00006509003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002151751,0.00447078,0.0007578926,0.0002484002,0.00009985247,0.0001245277,0.0001053883,0.002021482,0.9809427,0.0002057861,0.0005490907,0.008322333],"study_design_scores_gemma":[0.000572794,0.06395756,0.004178289,0.00002777645,0.0001885969,0.0001648588,0.00006463813,0.002391297,0.9240426,0.00008691651,0.004303328,0.00002133717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862007,0.002570029,0.005292687,0.0002129988,0.0002405041,0.0009328802,0.002088775,0.000225625,0.002235563],"genre_scores_gemma":[0.9846182,0.002302371,0.005307232,0.0001485885,0.00005523544,0.0006809477,0.004067083,0.00003611246,0.002784179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001334953,"threshold_uncertainty_score":0.005640924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1068234967288046,"score_gpt":0.4183513994931181,"score_spread":0.3115279027643135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}