{"id":"W4386100118","doi":"10.1038/s43856-023-00340-7","title":"Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells","year":2023,"lang":"en","type":"article","venue":"Communications Medicine","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; National Research Council Canada","funders":"","keywords":"Chinese hamster ovary cell; Virus-like particle; Virology; Cricetulus; Biology; Antigen; Virus; Glycosylation; Hamster; In vivo; Titer; Antibody; Cell culture; Cell biology; Molecular biology; Recombinant DNA; Immunology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001107521,0.0001204915,0.0001836935,0.0001030982,0.00008414418,0.000006468513,0.0004228372,0.00009290936,0.00003741969],"category_scores_gemma":[0.0007238084,0.00009482031,0.00006150357,0.0003269385,0.0002107167,0.000008503212,0.000300328,0.0001164879,0.00002918064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001613378,"about_ca_system_score_gemma":0.00009868227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001370663,"about_ca_topic_score_gemma":0.0002348516,"domain_scores_codex":[0.9985598,0.0003583813,0.0004316768,0.0002501488,0.0002384202,0.000161511],"domain_scores_gemma":[0.9980289,0.00008032061,0.0001397471,0.001515373,0.0001821648,0.00005346537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005385142,0.0001787192,0.006392584,0.00002263549,0.00002477356,3.707254e-7,0.0001737119,0.0002882785,0.9667664,0.000008822816,0.02301994,0.003069968],"study_design_scores_gemma":[0.001871357,0.0003321369,0.03953629,0.0001371957,0.00007300506,0.000002753956,0.0001375455,0.006788353,0.9387425,0.00120935,0.01098594,0.0001835449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950784,0.001828635,0.00002508392,0.001408038,0.0002426813,0.0004059236,0.00001342193,0.00002527772,0.0009725072],"genre_scores_gemma":[0.9975452,0.001196215,0.0001470819,0.0004579262,0.0001027248,0.0001459213,0.0002890728,0.00001568579,0.0001001871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03314371,"threshold_uncertainty_score":0.386666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1068234967288046,"score_gpt":0.4183513994931181,"score_spread":0.3115279027643135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}