{"id":"W4386102194","doi":"10.1016/j.jbc.2023.105189","title":"Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase","year":2023,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Institute for Protein Research, Osaka University; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Allopurinol; Xanthine oxidase; Oxidoreductase; Xanthine dehydrogenase; Chemistry; Biochemistry; Xanthine; Pharmacology; Enzyme; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001997773,0.0004239579,0.000370415,0.0002772575,0.0001411411,0.0005761365,0.0004548907,0.0005174352,0.001404925],"category_scores_gemma":[0.0003444921,0.0001690925,0.0003695361,0.0003083289,0.0002749499,0.0004144072,0.0002445259,0.0007124522,0.0004600464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003022556,"about_ca_system_score_gemma":0.0001374969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004064462,"about_ca_topic_score_gemma":0.0004190333,"domain_scores_codex":[0.9994829,0.00007725598,0.00004356766,0.0001025782,0.0001988983,0.00009479242],"domain_scores_gemma":[0.9996852,0.00005178587,0.0001408533,0.00003634956,0.00004621652,0.00003956741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002188506,0.0000628175,0.0008777468,0.0002159622,0.00004499445,0.0001141125,0.00003067296,0.0002883213,0.9858709,0.0004734177,0.00007516234,0.01172704],"study_design_scores_gemma":[0.0000296246,0.0008516212,0.008045635,0.00001742434,0.00004936866,0.0008290493,0.0000383028,0.0007719074,0.9771772,0.0001549161,0.01202023,0.00001467156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9469458,0.0312119,0.01184591,0.00037673,0.0001783669,0.0001289709,0.0009386778,0.0001861151,0.008187558],"genre_scores_gemma":[0.985957,0.005259071,0.004988837,0.0002484285,0.00004546989,0.00005588892,0.000631887,0.00002747068,0.002785771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404925,"threshold_uncertainty_score":0.004699886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224348995781928,"score_gpt":0.2480649430163319,"score_spread":0.2256300434381391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}