{"id":"W4386107242","doi":"10.14283/jpad.2023.99","title":"Association of Blood MicroRNA Expression and Polymorphisms with Cognitive and Biomarker Changes in Older Adults","year":2023,"lang":"en","type":"article","venue":"The Journal of Prevention of Alzheimer s Disease","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; Horizon 2020 Framework Programme; Genentech; National Institutes of Health; IXICO; Conseil Régional Hauts-de-France; Deutsches Zentrum für Neurodegenerative Erkrankungen; H. Lundbeck A/S; Servier; Eisai; Imperial College London; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Canadian Institutes of Health Research; Diabetes UK; Agence Nationale de la Recherche; F. Hoffmann-La Roche; Stiftung VERUM; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; European Commission; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"TREM2; Biomarker; Dementia; Oncology; Cognitive decline; microRNA; Expression quantitative trait loci; Disease; Genome-wide association study; Internal medicine; Medicine; Bioinformatics; Biology; Single-nucleotide polymorphism; Gene; Genotype; Genetics; Inflammation; Microglia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003500885,0.0002700561,0.000311436,0.0004166603,0.0002068962,0.0003675463,0.0001617008,0.0003842324,0.0008930856],"category_scores_gemma":[0.001124644,0.0001794706,0.0002652452,0.0004687736,0.0001086273,0.0001386199,0.0001811001,0.0002686708,0.0001862465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001381938,"about_ca_system_score_gemma":0.0001228009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000969818,"about_ca_topic_score_gemma":0.0009353884,"domain_scores_codex":[0.999803,0.00003521594,0.00002073839,0.00008897986,0.00003125833,0.00002088532],"domain_scores_gemma":[0.9995255,0.00009520344,0.0002183064,0.0000381418,0.00007708353,0.00004571301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001655514,0.00006297628,0.9820023,0.00003938573,0.0002029854,0.0001083138,0.00009296513,0.00008548355,0.01129377,0.00003697735,0.0002346093,0.00418483],"study_design_scores_gemma":[0.00001401515,0.0001359277,0.9983871,0.000004227159,0.00007212856,0.0002025849,0.00003213856,0.0001861509,0.0007445902,0.00004787919,0.0001702288,0.000003136497],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986676,0.0003215601,0.0001993963,0.00002248462,0.000005422258,0.000004594259,0.0005809586,0.000007582011,0.0001903419],"genre_scores_gemma":[0.9985949,0.0001312948,0.0003947478,0.00003733555,0.00001156087,0.00002026355,0.0004999471,0.000004208088,0.0003056997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000969818,"threshold_uncertainty_score":0.002987683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072958941082442,"score_gpt":0.2556376652807016,"score_spread":0.2449080758698772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}