{"id":"W4386107242","doi":"10.14283/jpad.2023.99","title":"Association of Blood MicroRNA Expression and Polymorphisms with Cognitive and Biomarker Changes in Older Adults","year":2023,"lang":"en","type":"article","venue":"The Journal of Prevention of Alzheimer s Disease","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; Horizon 2020 Framework Programme; Genentech; National Institutes of Health; IXICO; Conseil Régional Hauts-de-France; Deutsches Zentrum für Neurodegenerative Erkrankungen; H. Lundbeck A/S; Servier; Eisai; Imperial College London; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Canadian Institutes of Health Research; Diabetes UK; Agence Nationale de la Recherche; F. Hoffmann-La Roche; Stiftung VERUM; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; European Commission; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"TREM2; Biomarker; Dementia; Oncology; Cognitive decline; microRNA; Expression quantitative trait loci; Disease; Genome-wide association study; Internal medicine; Medicine; Bioinformatics; Biology; Single-nucleotide polymorphism; Gene; Genotype; Genetics; Inflammation; Microglia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003980234,0.00007309132,0.0001154372,0.00009619437,0.00002128569,0.000004345566,0.0000489914,0.0000445467,0.00001185918],"category_scores_gemma":[0.00006374976,0.00005186716,0.00004033757,0.000100719,0.00005860587,0.00001082672,0.00004574209,0.00003709528,1.861357e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000313065,"about_ca_system_score_gemma":0.00004144125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003733256,"about_ca_topic_score_gemma":0.00000952124,"domain_scores_codex":[0.9993117,0.000156545,0.0002201225,0.00008409355,0.0001496195,0.00007794466],"domain_scores_gemma":[0.9991724,0.00002842869,0.0005117189,0.00007611689,0.0001492048,0.00006215632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002125132,0.0002243668,0.03501476,0.0000728447,0.000526725,0.000004385963,0.0003066591,0.000009188681,0.9586248,0.000001741731,0.0001914688,0.002897876],"study_design_scores_gemma":[0.002176813,0.0001876507,0.6811969,0.0005691108,0.0008668865,0.000007289519,0.0001856141,0.00002213563,0.3146695,0.00005085534,0.000007274006,0.00005997529],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918498,0.00760445,0.00005119761,0.0002466956,0.00002034159,0.0001890743,0.00003119491,0.000001580396,0.000005692578],"genre_scores_gemma":[0.999149,0.0006968294,0.00004669035,0.00001423236,0.00002599818,0.000003171608,0.00002136233,0.00000856753,0.0000341189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6461822,"threshold_uncertainty_score":0.2115081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072958941082442,"score_gpt":0.2556376652807016,"score_spread":0.2449080758698772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}