{"id":"W4386116271","doi":"10.2217/pgs-2023-0097","title":"Effects of <i>CYP3A4</i> and <i>CYP2C9</i> Genotype on Systemic Anastrozole and Fulvestrant Concentrations in SWOG S0226","year":2023,"lang":"en","type":"article","venue":"Pharmacogenomics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; American Association of Colleges of Pharmacy; Breast Cancer Research Foundation","keywords":"Anastrozole; Fulvestrant; Oncology; CYP2C9; Genotype; Internal medicine; Medicine; CYP3A4; Pharmacology; Dosing; Endocrine system; Tamoxifen; Breast cancer; Cancer; Hormone; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006849859,0.0003433826,0.0004851682,0.0002450039,0.0001713648,0.00002424271,0.0002338859,0.0001965897,0.00004548723],"category_scores_gemma":[0.00002976913,0.0003602122,0.00007760252,0.0004872492,0.0002564237,0.00009697807,0.0001423277,0.0005904714,0.00005855267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004660302,"about_ca_system_score_gemma":0.0001014708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002177721,"about_ca_topic_score_gemma":0.000004536164,"domain_scores_codex":[0.9977747,0.0003506761,0.0005817318,0.0004877877,0.0001768048,0.0006283213],"domain_scores_gemma":[0.9986139,0.000602167,0.0001901392,0.000162758,0.00006119132,0.0003698307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004144043,0.0002291424,0.009274159,0.0005272389,0.000198311,0.0001418354,0.001287687,0.002575618,0.9658744,0.001314255,0.0005547908,0.01760811],"study_design_scores_gemma":[0.01061953,0.0002048774,0.01559499,0.0001405945,0.0006506799,0.00009842457,0.0002391802,0.01747077,0.9166877,0.0007333286,0.03682374,0.0007362082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885139,0.008250091,0.00003160498,0.0003183979,0.001066591,0.0008780967,0.000223631,0.00008978879,0.0006278349],"genre_scores_gemma":[0.9736207,0.02466867,0.00009092948,0.001181546,0.0001844182,0.00008311128,0.00003252872,0.00004786494,0.00009020434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04918678,"threshold_uncertainty_score":0.999885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05199140185514887,"score_gpt":0.3800571171164778,"score_spread":0.3280657152613289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}