{"id":"W4386117018","doi":"10.1172/jci170341","title":"Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institute on Minority Health and Health Disparities; National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve University; University of Texas Health Science Center at San Antonio; Perelman School of Medicine, University of Pennsylvania; Centers for Disease Control and Prevention; National Institutes of Health; George Institute for Global Health; Idorsia Pharmaceuticals; University of Pennsylvania; Novo Nordisk; Bristol-Myers Squibb; Cleveland Clinic; Rijksuniversiteit Groningen; Maze Therapeutics; University of California, San Francisco; Horizon Pharma; Deutsches Krebsforschungszentrum; Johns Hopkins University; Eidgenössische Technische Hochschule Zürich; National University of Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University; Michigan Institute for Clinical and Health Research; Eli Lilly and Company; Kaiser Permanente; Georgia Clinical and Translational Science Alliance; Gilead Sciences; Boettcher Foundation; Pacific Northwest National Laboratory; Universitair Medisch Centrum Groningen; University of Colorado School of Medicine, Anschutz Medical Campus; University of Illinois at Urbana-Champaign; European Molecular Biology Laboratory; CSL Behring; AstraZeneca; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; American Heart Association; American Diabetes Association","keywords":"Medicine; Kidney disease; Albuminuria; Diabetes mellitus; Diabetic nephropathy; Kidney; Internal medicine; Endocrinology; Renal function; Biomarker; Microalbuminuria; PI3K/AKT/mTOR pathway; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007630141,0.0004287944,0.0005525532,0.0007704627,0.0003050335,0.001014831,0.0003240356,0.0004419484,0.001616453],"category_scores_gemma":[0.0005199969,0.0002032164,0.0005266101,0.0008828797,0.0002916413,0.0003868099,0.0006210039,0.0009413823,0.0002376081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004320644,"about_ca_system_score_gemma":0.0004389083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00186927,"about_ca_topic_score_gemma":0.002443251,"domain_scores_codex":[0.9996536,0.0001051206,0.00003025045,0.00006968038,0.00008350035,0.00005782141],"domain_scores_gemma":[0.9996607,0.00003019872,0.0001401924,0.00004580447,0.00004191334,0.00008113746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02490391,0.002766007,0.8145207,0.0005544442,0.001107036,0.0009654575,0.0002284183,0.001492281,0.09782708,0.001110971,0.002263385,0.05226045],"study_design_scores_gemma":[0.0003758497,0.003010107,0.945827,0.0001247537,0.0009772815,0.001804842,0.0004619846,0.007382204,0.03300171,0.001834775,0.005123476,0.00007611653],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906954,0.004522344,0.00132019,0.0003472017,0.00006914254,0.00002986727,0.001035983,0.00005110957,0.001928855],"genre_scores_gemma":[0.9965423,0.001140997,0.0007255632,0.0001683289,0.00002825446,0.00002449801,0.0006233534,0.000005135096,0.0007415085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00186927,"threshold_uncertainty_score":0.005407572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06025230152040864,"score_gpt":0.3287058656259496,"score_spread":0.2684535641055409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}