{"id":"W4386117339","doi":"10.1152/ajprenal.00145.2023","title":"Coupling of renal sodium and calcium transport: a modeling analysis of transporter inhibition and sex differences","year":2023,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Nephron; Reabsorption; Paracellular transport; Convoluted tubule; Distal convoluted tubule; Internal medicine; Chemistry; Endocrinology; Kidney; Transcellular; Tubule; Ion transporter; Renal physiology; Tubuloglomerular feedback; Tubular fluid; Biophysics; Biology; Medicine; Biochemistry; Permeability (electromagnetism); Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002051111,0.0001848092,0.0007960255,0.0003353961,0.00004776116,0.000002013615,0.00009885458,0.0001153669,0.00001012934],"category_scores_gemma":[0.000006475922,0.0001518808,0.0002640239,0.0004357925,0.000607945,0.00001291057,0.00001747126,0.0001335666,1.384391e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004461886,"about_ca_system_score_gemma":0.00004948904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000052681,"about_ca_topic_score_gemma":0.00001955871,"domain_scores_codex":[0.9986659,0.00004648843,0.0006521704,0.0002802548,0.0001335997,0.0002216394],"domain_scores_gemma":[0.9990057,0.00003361928,0.0005787249,0.0001348246,0.0001659095,0.00008121117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005665092,0.00005015479,0.003494767,0.00004160835,0.0007442266,0.000001795155,0.0003490458,0.03611557,0.9581934,0.00001986844,0.00000462139,0.0004184699],"study_design_scores_gemma":[0.00132028,0.002684921,0.6698012,0.00009410368,0.001297249,0.0000172216,0.001192108,0.05245053,0.2699964,0.0007771403,0.00001634039,0.000352505],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971854,0.0001727806,0.002427336,0.00005052821,0.00004766372,0.00005850787,0.00004895863,0.00000534778,0.000003451345],"genre_scores_gemma":[0.9989975,0.0005032293,0.00009776298,0.00003098152,0.0001329618,0.000003066096,0.0002130804,0.00001307316,0.00000832838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6881969,"threshold_uncertainty_score":0.6193521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134889495226909,"score_gpt":0.2437543702020279,"score_spread":0.230265420679337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}