{"id":"W4386117339","doi":"10.1152/ajprenal.00145.2023","title":"Coupling of renal sodium and calcium transport: a modeling analysis of transporter inhibition and sex differences","year":2023,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Nephron; Reabsorption; Paracellular transport; Convoluted tubule; Distal convoluted tubule; Internal medicine; Chemistry; Endocrinology; Kidney; Transcellular; Tubule; Ion transporter; Renal physiology; Tubuloglomerular feedback; Tubular fluid; Biophysics; Biology; Medicine; Biochemistry; Permeability (electromagnetism); Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002159665,0.0003704591,0.0006274894,0.000282075,0.0003566305,0.000533296,0.0008557189,0.001097459,0.002069599],"category_scores_gemma":[0.0007428812,0.0002833942,0.0008661213,0.0002786214,0.0003622653,0.0003782054,0.000373087,0.0004015526,0.0001430274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007567119,"about_ca_system_score_gemma":0.001047838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02004088,"about_ca_topic_score_gemma":0.009052039,"domain_scores_codex":[0.9999404,0.00001590868,0.000002310559,0.00001308436,0.000008187713,0.00002015485],"domain_scores_gemma":[0.9997762,0.0001090909,0.00003740167,0.00001405018,0.00003512115,0.00002806743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00007361169,0.00005314226,0.001690311,0.00001692157,0.00002828915,0.00008049397,0.00002776404,0.9905462,0.002161395,0.004051098,0.0002061673,0.001064613],"study_design_scores_gemma":[0.00001359762,0.00001353367,0.0003636951,0.000001287555,0.00001241431,0.000007986585,0.00000904876,0.9988562,0.0001320656,0.0004701673,0.0001164163,0.000003536179],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9563165,0.0002193634,0.02887753,0.0006387093,0.00003872677,0.00003034601,0.00044273,0.0001114672,0.0133245],"genre_scores_gemma":[0.9939352,0.00009852675,0.002958321,0.00007857125,0.000009918012,0.00004310148,0.00009327667,0.00002966689,0.002753439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02004088,"threshold_uncertainty_score":0.03984845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0134889495226909,"score_gpt":0.2437543702020279,"score_spread":0.230265420679337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}