{"id":"W4386121817","doi":"10.21203/rs.3.rs-2927895/v3","title":"Anticancer analysis of CD44 targeted Cyclosporine loaded thiolated chitosan nanoformulations for sustained release in triple-negative breast cancer.","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Response Biomedical (Canada)","funders":"King Abdulaziz University","keywords":"Zeta potential; Chitosan; Chemistry; Nanocarriers; Drug delivery; Triple-negative breast cancer; Pharmacology; Drug; Breast cancer; Materials science; Nanoparticle; Nanotechnology; Cancer; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009880643,0.0001314533,0.0001139323,0.0001140843,0.00008940985,0.0001120709,0.00008843574,0.0001571335,0.0008342082],"category_scores_gemma":[0.00009391349,0.00005700068,0.0001377501,0.0001188881,0.00009009772,0.00009562961,0.00005368568,0.0001546231,0.0001334871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002396039,"about_ca_system_score_gemma":0.0001623023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001794789,"about_ca_topic_score_gemma":0.00231907,"domain_scores_codex":[0.9999608,0.000004135793,0.00000252588,0.000008803299,0.00001311708,0.00001067128],"domain_scores_gemma":[0.9999632,0.000007727863,0.000009825545,0.000002381377,0.000009761558,0.000007197556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000737179,0.000014561,0.0000447218,0.00002371359,0.000002315518,0.00001212744,0.000006893051,0.00009546139,0.9986312,0.00001889935,0.00002688466,0.00104958],"study_design_scores_gemma":[0.000008917341,0.0002216036,0.001039304,0.00000157335,0.000008605331,0.00002573592,0.000006639267,0.0007142345,0.9975628,0.000003146473,0.0004049917,0.000002496632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962574,0.001007941,0.00147067,0.0000350118,0.00001434306,0.00003369824,0.0001966911,0.00003285455,0.0009514657],"genre_scores_gemma":[0.9952008,0.0007215609,0.001796177,0.00001678306,0.000004366022,0.00002514618,0.000159801,0.00001187107,0.002063447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001794789,"threshold_uncertainty_score":0.003568709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05015648454353045,"score_gpt":0.3857105592343217,"score_spread":0.3355540746907913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}