{"id":"W4386125580","doi":"10.1186/s12967-023-04452-5","title":"Inhibiting NLRP3 inflammasome signaling pathway promotes neurological recovery following hypoxic-ischemic brain damage by increasing p97-mediated surface GluA1-containing AMPA receptors","year":2023,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Neonatal and fetal brain pathology","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health","funders":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission; Natural Science Foundation of Chongqing; Chongqing Medical University; Chongqing Municipal Education Commission; National Natural Science Foundation of China; Heart and Stroke Foundation of British Columbia and Yukon; Fudan University; Heart and Stroke Foundation of Canada","keywords":"AMPA receptor; Inflammasome; Receptor; Medicine; Brain damage; Neuroscience; Glutamate receptor; Pharmacology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002251706,0.0004743729,0.0006347655,0.0002940917,0.0001746815,0.0002411834,0.0002816858,0.0003035548,0.001940551],"category_scores_gemma":[0.0002318701,0.0001045103,0.0004598,0.000206737,0.0003528202,0.0003829006,0.0002506043,0.001017012,0.0004557493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000155562,"about_ca_system_score_gemma":0.0002703015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001496469,"about_ca_topic_score_gemma":0.0002379743,"domain_scores_codex":[0.999805,0.00002209553,0.00003617553,0.00003145323,0.0000483623,0.00005687688],"domain_scores_gemma":[0.9998652,0.00001054898,0.0000521659,0.000012064,0.00001934081,0.00004071842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002090322,0.0004414748,0.0005791157,0.0005508245,0.00004981491,0.000232648,0.00005634744,0.0001473118,0.9871626,0.0001750097,0.0005044242,0.00801011],"study_design_scores_gemma":[0.0003110373,0.003297888,0.01025193,0.00008100377,0.0001381791,0.0007197853,0.0001264798,0.001430104,0.9793984,0.0002825474,0.003947964,0.00001460893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843685,0.007404053,0.005172519,0.000374791,0.0001753853,0.00008012923,0.0004465111,0.0002836188,0.001694473],"genre_scores_gemma":[0.989369,0.004719801,0.00283193,0.0001799236,0.00007079606,0.0002458886,0.0005660275,0.00003640365,0.001980316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001940551,"threshold_uncertainty_score":0.00649178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042638390266753,"score_gpt":0.2620415762093771,"score_spread":0.2416151923067095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}