{"id":"W4386127485","doi":"10.20944/preprints202308.1707.v1","title":"How Does cGAS Avoid to Sense Self-DNA under Normal Physiological Conditions?","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Saskatchewan","funders":"Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China","keywords":"Cell biology; DNA; Mitochondrial DNA; Biology; Sense (electronics); Innate immune system; Cytosol; Signal transducing adaptor protein; Chemistry; Genetics; Gene; Biochemistry; Signal transduction; Immune system; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004003358,0.0005273611,0.0006694293,0.0004218036,0.0003294635,0.001599355,0.0003787137,0.001359257,0.001433861],"category_scores_gemma":[0.0004170926,0.0002024336,0.0005009359,0.0002414797,0.0008186459,0.001379973,0.0004654704,0.001387496,0.001292819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005675156,"about_ca_system_score_gemma":0.0004319524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000280692,"about_ca_topic_score_gemma":0.0002266992,"domain_scores_codex":[0.9996817,0.00005186893,0.00002045165,0.0000885238,0.00008158743,0.00007578511],"domain_scores_gemma":[0.999855,0.00002944997,0.0000391451,0.00001332856,0.00004005643,0.00002302288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000461553,0.00007067676,0.001860438,0.00586334,0.0001508046,0.001603564,0.0008710839,0.0006899278,0.7790841,0.04327899,0.007358071,0.1587074],"study_design_scores_gemma":[0.00002958004,0.0005384321,0.005984206,0.0008907079,0.0001730559,0.006085317,0.001069907,0.001390127,0.4341022,0.02211414,0.5274994,0.0001229967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1002636,0.8108785,0.03765056,0.01004668,0.003401308,0.0001360429,0.0006538435,0.0007187499,0.03625077],"genre_scores_gemma":[0.5136093,0.4320251,0.01189826,0.005421418,0.001480476,0.0002133233,0.0008507725,0.0001636633,0.03433762],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001599355,"threshold_uncertainty_score":0.004796684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1143342150694917,"score_gpt":0.3400419732745782,"score_spread":0.2257077582050865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}