{"id":"W4386142532","doi":"10.2196/51783","title":"A Hospital-Wide Open-Label Cluster Crossover Pragmatic Comparative Effectiveness Randomized Trial Comparing Normal Saline to Ringer’s Lactate: Protocol and Statistical Analysis Plan of The FLUID Trial","year":2023,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Trauma, Hemostasis, Coagulopathy, Resuscitation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Children's Hospital of Eastern Ontario; St. Joseph’s Healthcare Hamilton; McMaster University; London Health Sciences Centre; Minnow Environmental (Canada); St. Michael's Hospital; Western University; Ottawa Hospital; Thrombosis and Atherosclerosis Research Institute; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Crossover study; Protocol (science); Randomized controlled trial; Medicine; Cluster (spacecraft); Saline; Statistical analysis; Physical therapy; Computer science; Anesthesia; Surgery; Statistics; Alternative medicine; Placebo; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05900973,0.00720992,0.00999586,0.003307559,0.002955312,0.00615594,0.003563528,0.006450079,0.0384043],"category_scores_gemma":[0.06439389,0.003361428,0.00620295,0.004153281,0.004618547,0.003044496,0.002255698,0.007039526,0.006968727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006992843,"about_ca_system_score_gemma":0.02532397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004169779,"about_ca_topic_score_gemma":0.00561345,"domain_scores_codex":[0.9543198,0.03437622,0.002698565,0.002789338,0.003506411,0.002309615],"domain_scores_gemma":[0.9763461,0.008175968,0.004131007,0.003069977,0.005254555,0.003022347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8700957,0.01375202,0.002120792,0.02229147,0.00587751,0.0005430536,0.000750763,0.007410871,0.001795374,0.01327485,0.03069228,0.03139529],"study_design_scores_gemma":[0.9225495,0.02416635,0.002420906,0.003372899,0.002551987,0.0001040937,0.0002228886,0.006748736,0.0009701716,0.006614916,0.03008122,0.0001962716],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.002172379,0.0001939619,0.001867614,0.0002845132,0.0003014214,0.9931108,0.00119669,0.00007068159,0.0008020361],"genre_scores_gemma":[0.002128603,0.00007966097,0.002852576,0.0001815068,0.0000373056,0.9942898,0.0001877505,0.000004616181,0.000238281],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05900973,"threshold_uncertainty_score":0.312077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2505775396918606,"score_gpt":0.5596461166393673,"score_spread":0.3090685769475067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}