{"id":"W4386150974","doi":"10.1007/s00109-023-02359-8","title":"Role of the pioneer transcription factor GATA2 in health and disease","year":2023,"lang":"en","type":"review","venue":"Journal of Molecular Medicine","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Government of Ontario; Heart and Stroke Foundation of Canada","keywords":"GATA2; Cancer research; Biology; Myeloid leukemia; Immunology; GATA transcription factor; Transcription factor; Medicine; Genetics; Gene; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008545585,0.001047579,0.001415716,0.001354258,0.0002354813,0.001020876,0.001062129,0.001363335,0.002691438],"category_scores_gemma":[0.0007986265,0.0003578909,0.0003511995,0.001575673,0.0007477418,0.001073665,0.0008579636,0.002328877,0.001793941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008366235,"about_ca_system_score_gemma":0.001032132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009670302,"about_ca_topic_score_gemma":0.002162444,"domain_scores_codex":[0.9998567,0.00002192361,0.00001649987,0.00002979808,0.00005556586,0.00001959674],"domain_scores_gemma":[0.9996899,0.0001463309,0.00003833849,0.00001066187,0.00007336926,0.0000412934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000196335,0.00005616388,0.0001890902,0.009125122,0.000107673,0.0002172914,0.0000407385,0.0006298986,0.003368113,0.006227064,0.05554339,0.9242991],"study_design_scores_gemma":[0.00003178213,0.00005921917,0.0005710846,0.001202027,0.00009226771,0.0005722069,0.00002703709,0.0001095462,0.0006916371,0.002347316,0.9942802,0.00001572121],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005867605,0.9987428,0.0001146409,0.0002965228,0.0003253589,0.000001744474,0.00001127708,0.000005111004,0.0004439059],"genre_scores_gemma":[0.0004976998,0.9982061,0.0001406888,0.0002414807,0.0003902667,0.000003830066,0.0000215252,0.000001383434,0.0004970452],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002691438,"threshold_uncertainty_score":0.009003818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03508673720986964,"score_gpt":0.3377583817998757,"score_spread":0.3026716445900061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}