{"id":"W4386151888","doi":"10.1080/19420862.2023.2248672","title":"Unique epitope–antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display","year":2023,"lang":"en","type":"article","venue":"mAbs","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Epitope; Chemistry; Epitope mapping; Nuclear magnetic resonance spectroscopy; Carbonic anhydrase; Linear epitope; Biochemistry; Surface plasmon resonance; Biophysics; Antibody; Molecular biology; Biology; Enzyme; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001850386,0.0003956342,0.0002512112,0.0001094424,0.00009922934,0.000208385,0.0003030974,0.0002688443,0.0004263747],"category_scores_gemma":[0.0001802659,0.0001536922,0.0001868292,0.0001064967,0.0001100791,0.0001366198,0.0001924391,0.0003599864,0.0001921373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002386939,"about_ca_system_score_gemma":0.00008833989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005671302,"about_ca_topic_score_gemma":0.0008518387,"domain_scores_codex":[0.9997787,0.00006012207,0.000009484685,0.0000459406,0.00005855882,0.00004719656],"domain_scores_gemma":[0.9999057,0.00003240125,0.00001716294,0.000008401556,0.00001772593,0.00001861503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003002088,0.00001561909,0.00007187959,0.000009640101,0.000003708436,0.00002052845,0.000007893981,0.00009741693,0.9993277,0.00002758499,0.00001085343,0.0003772268],"study_design_scores_gemma":[0.00001291661,0.0001644325,0.001697933,0.00000206435,0.00001079692,0.0001133003,0.00001525603,0.004389273,0.9928648,0.00002429447,0.0006994061,0.000005452284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943929,0.000304339,0.004581921,0.00002772678,0.000006837676,0.00001519931,0.00004903564,0.0000297774,0.0005922283],"genre_scores_gemma":[0.993607,0.0001628483,0.005429723,0.00004440295,0.000003344391,0.00001408904,0.0001361578,0.00001198213,0.0005904213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005671302,"threshold_uncertainty_score":0.001731813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007115238545590655,"score_gpt":0.2498012036793931,"score_spread":0.2426859651338024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}