{"id":"W4386152924","doi":"10.15252/embj.2023113933","title":"The EDC4‐XRN1 interaction controls P‐body dynamics to link mRNA decapping with decay","year":2023,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"P-bodies; Messenger RNA; Messenger RNP; Biology; RNA-binding protein; Cell biology; Ribonucleoprotein; Exonuclease; Stress granule; Nonsense-mediated decay; RNA; Cytoplasm; Molecular biology; Biochemistry; Translation (biology); Enzyme; Gene; RNA splicing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001902627,0.0003019192,0.0002690279,0.0001103298,0.0002279011,0.0004406649,0.0003198351,0.0003274067,0.001407653],"category_scores_gemma":[0.0001965622,0.0002210281,0.000211227,0.0001178886,0.0002876593,0.0002365922,0.0003331635,0.0004659447,0.0004052828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006605749,"about_ca_system_score_gemma":0.0002378465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007702616,"about_ca_topic_score_gemma":0.0009467148,"domain_scores_codex":[0.9998108,0.00002663357,0.00001641098,0.00007495673,0.00003525701,0.00003594581],"domain_scores_gemma":[0.9998791,0.00002307041,0.0000420019,0.00001593613,0.00001400887,0.00002580717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000861431,0.00001396539,0.0002388261,0.00001883439,0.000003451407,0.0000336747,0.000008360842,0.0001121102,0.9985099,0.0001336303,0.0000302027,0.0008108469],"study_design_scores_gemma":[0.00001143175,0.00003370586,0.004207671,0.000002816277,0.000005983555,0.000079545,0.00001195429,0.001895436,0.9924596,0.0000360503,0.001251802,0.000003982909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903795,0.002193241,0.005616561,0.0001581603,0.00003568872,0.00001227783,0.000158051,0.0001300089,0.001316512],"genre_scores_gemma":[0.9945841,0.0004868119,0.0022967,0.00004329207,0.000004974423,0.00001756938,0.000204513,0.00003135148,0.002330646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001407653,"threshold_uncertainty_score":0.004792809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128778785650823,"score_gpt":0.2947223479205711,"score_spread":0.2834345600640629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}