{"id":"W4386153382","doi":"10.1152/ajpheart.00362.2023","title":"Dual effects of the small-conductance Ca <sup>2+</sup> -activated K <sup>+</sup> current on human atrial electrophysiology and Ca <sup>2+</sup> -driven arrhythmogenesis: an in silico study","year":2023,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; European Commission; American Heart Association","keywords":"Afterdepolarization; Repolarization; Cardiac electrophysiology; Refractory period; Atrial action potential; Atrial fibrillation; Electrophysiology; Effective refractory period; Internal medicine; Cardiology; Depolarization; Reentry; Sinus rhythm; Conductance; Chemistry; Medicine; Biophysics; Biology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001902191,0.000312704,0.000545247,0.0001581252,0.00018679,0.0004304014,0.000517825,0.0009241244,0.001531314],"category_scores_gemma":[0.0007433327,0.000149314,0.0005128903,0.0001550981,0.0003794431,0.000396319,0.000317385,0.0003177995,0.0001668205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002534394,"about_ca_system_score_gemma":0.0004076769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002795236,"about_ca_topic_score_gemma":0.001847451,"domain_scores_codex":[0.9999437,0.0000156091,0.000003005209,0.00001252319,0.00001255814,0.00001260389],"domain_scores_gemma":[0.9997337,0.0001831071,0.00002208993,0.00001424682,0.00002769586,0.00001924178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001077439,0.00005622407,0.001983217,0.0001277206,0.00004366251,0.0003367787,0.00006701909,0.9717022,0.02177869,0.001999738,0.0001917078,0.001605245],"study_design_scores_gemma":[0.00003120181,0.00009162434,0.0007177104,0.000008220907,0.00002427241,0.0000506197,0.00002527173,0.9945294,0.003449876,0.0006866382,0.0003754707,0.000009629968],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9643149,0.0004331269,0.02618569,0.0003586781,0.00004893219,0.0000410373,0.0004742392,0.0001180095,0.008025402],"genre_scores_gemma":[0.9969831,0.000202763,0.002152221,0.00004982208,0.000007231672,0.00002105023,0.00008161323,0.00001392618,0.0004881868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002795236,"threshold_uncertainty_score":0.005557895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751078135626022,"score_gpt":0.2801509570602002,"score_spread":0.2626401757039399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}