{"id":"W4386153523","doi":"10.1096/fj.202300349r","title":"Muscle p62 stimulates the expression of antioxidant proteins alleviating cancer cachexia","year":2023,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Nutrition and Health in Aging","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; National Institutes of Health; Uehara Memorial Foundation; National Institute on Aging; Nagoya City University; Nakatomi Foundation; China Medical University; York University; Suzuken Memorial Foundation","keywords":"Cachexia; Skeletal muscle; Muscle atrophy; Glycolysis; Internal medicine; Endocrinology; Phosphorylation; Wasting; Oxidative phosphorylation; Biology; KEAP1; Oxidative stress; Transcription factor; Chemistry; Biochemistry; Cancer; Medicine; Metabolism; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009263657,0.00007230373,0.0001516337,0.0000669355,0.000422168,0.00001929357,0.0001192716,0.00003107281,0.0002826385],"category_scores_gemma":[0.00009813717,0.00003438221,0.00007497097,0.0002157197,0.00005939255,0.00004384625,0.00004055032,0.0004161011,0.00001794473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003817731,"about_ca_system_score_gemma":0.0001117696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006391552,"about_ca_topic_score_gemma":0.000006799453,"domain_scores_codex":[0.9990056,0.0001074276,0.0002922149,0.00007376078,0.0003010043,0.0002200212],"domain_scores_gemma":[0.9993351,0.0001240234,0.0001942112,0.000159255,0.00009921396,0.00008826325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007541545,0.00004417756,0.00922116,0.0001413814,0.00002205109,0.00002652919,0.00200547,0.0003188902,0.9799682,0.00004875233,0.003041018,0.00508693],"study_design_scores_gemma":[0.004278371,0.0003224183,0.3191404,0.005093041,0.0001563861,0.0003615342,0.005838196,0.008972346,0.6475091,0.00165312,0.006459005,0.0002160276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849682,0.0008261894,0.0001385168,0.01323139,0.0001965847,0.000306863,0.000006056621,0.00003587503,0.0002903664],"genre_scores_gemma":[0.9974046,0.000735258,0.0003422143,0.0006236017,0.0004635269,0.00001509217,0.00000159198,0.00001343083,0.0004006931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3324591,"threshold_uncertainty_score":0.3247018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06684976157396612,"score_gpt":0.3599028272571878,"score_spread":0.2930530656832217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}