{"id":"W4386157281","doi":"10.1126/sciimmunol.adg0878","title":"Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1 <sup>+</sup> PD-1 <sup>+</sup> CD8 T cells","year":2023,"lang":"en","type":"article","venue":"Science Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"Weill Cornell Medical College; National Cancer Institute; National Institutes of Health; Philippe Foundation; National Institute of Allergy and Infectious Diseases; University of Pittsburgh; Icahn School of Medicine at Mount Sinai; AstraZeneca","keywords":"CD28; Cytotoxic T cell; CD8; Biology; Cell biology; Effector; Immunology; Immune system; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001043643,0.0004571364,0.0007610722,0.001006403,0.0009390268,0.00005795181,0.0008883281,0.0007352004,0.0003186452],"category_scores_gemma":[0.0003836864,0.0004269067,0.0001901776,0.001366591,0.002469447,0.0004636337,0.0006765441,0.0004012988,0.0003930599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743921,"about_ca_system_score_gemma":0.0004091662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001817072,"about_ca_topic_score_gemma":0.000008117702,"domain_scores_codex":[0.9961741,0.0003254834,0.0008926162,0.001078458,0.0001490056,0.001380354],"domain_scores_gemma":[0.9974611,0.000702334,0.0004435075,0.0007958532,0.0005377146,0.00005953125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004687959,0.0002083285,0.001062739,0.00006327904,0.0002425322,0.000003423863,0.00401952,0.0004733791,0.9857664,0.002171289,0.001245894,0.004274483],"study_design_scores_gemma":[0.007388311,0.001838975,0.002967511,0.00006333846,0.0002336792,0.00008490797,0.00525539,0.01338596,0.9533963,0.005740409,0.008850374,0.000794831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945752,0.001186579,0.0005126452,0.000968291,0.0009564401,0.0009849763,0.00009683378,0.0003511856,0.0003678528],"genre_scores_gemma":[0.9950752,0.0004370266,0.0003109481,0.0001586478,0.00005290627,0.0001012475,0.0003146482,0.00004134605,0.003507981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03237003,"threshold_uncertainty_score":0.9998183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0136196420798656,"score_gpt":0.2484457212193447,"score_spread":0.2348260791394791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}