{"id":"W4386158167","doi":"10.1101/2023.08.25.554737","title":"Differential Regulation of Excitatory vs Inhibitory Synaptic Release by Complexin/CPX-1 and CAPS/UNC-31 at the <i>C. elegans</i> Neuromuscular Junctions","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network","funders":"National Key Research and Development Program of China; Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Excitatory postsynaptic potential; Excitatory synapse; Inhibitory postsynaptic potential; Biology; Neuromuscular junction; Synaptic vesicle; Cell biology; Synapse; Neuroscience; Vesicle; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067011,0.0003266472,0.0002158033,0.0001820114,0.000173694,0.0003796089,0.0002975534,0.0003147823,0.0005790418],"category_scores_gemma":[0.0001289078,0.0001828568,0.0001902665,0.0000688791,0.0002889087,0.0002680176,0.0003000915,0.0005069652,0.0001763675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004406933,"about_ca_system_score_gemma":0.0001338178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007879558,"about_ca_topic_score_gemma":0.001115061,"domain_scores_codex":[0.9998653,0.000009853737,0.00001734957,0.00003658828,0.00003898351,0.00003192657],"domain_scores_gemma":[0.9998255,0.00002135033,0.00006302657,0.00001401549,0.0000195658,0.000056507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002883421,0.000003744398,0.00008923802,0.0000100534,0.000001388025,0.00001802122,0.000003617101,0.00001959262,0.9996731,0.00002377436,0.000006100789,0.0001225334],"study_design_scores_gemma":[0.000007463255,0.00007364649,0.01164767,0.000006233553,0.00001028565,0.0001037839,0.00002595108,0.001491174,0.986192,0.00002356531,0.0004118387,0.000006509791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998471,0.0002713219,0.0006379602,0.00002339661,0.000007644914,0.000008764135,0.0001148805,0.00002549542,0.000439582],"genre_scores_gemma":[0.9981406,0.000142625,0.0007149225,0.00002483492,0.000002138809,0.00001659547,0.0001229967,0.00001767861,0.0008176399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007879558,"threshold_uncertainty_score":0.003197432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055378051117595,"score_gpt":0.1967113449828933,"score_spread":0.1861575644717173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}