{"id":"W4386161705","doi":"10.26685/urncst.495","title":"The Therapeutic Potential of HDAC Inhibitors for Dopamine Deficiency in Alzheimer’s Disease: A Research Protocol","year":2023,"lang":"en","type":"article","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Dopamine; Ventral tegmental area; Dopaminergic; Microdialysis; Dopamine transporter; Neurotransmitter; Chemistry; Pharmacology; Neuroscience; Medicine; Biology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002325925,0.001624674,0.00179387,0.0007631425,0.001058144,0.001075059,0.001855921,0.002479859,0.02658422],"category_scores_gemma":[0.001198678,0.000503367,0.002292057,0.0004728123,0.0005545415,0.0009360642,0.0008848908,0.002768109,0.004622112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001187408,"about_ca_system_score_gemma":0.004134127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00070756,"about_ca_topic_score_gemma":0.002157924,"domain_scores_codex":[0.9991242,0.0002712566,0.0001181832,0.0001468966,0.000182212,0.0001572997],"domain_scores_gemma":[0.9992543,0.000138457,0.0001107718,0.0001171949,0.0002072958,0.0001719937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.08201564,0.02233664,0.00117763,0.02157521,0.0006799467,0.002006394,0.0005087721,0.002121243,0.3270798,0.01673448,0.09677511,0.4269891],"study_design_scores_gemma":[0.04397466,0.1415367,0.004348699,0.003704612,0.001655732,0.002499937,0.0002746009,0.0010772,0.1408195,0.003801566,0.6561049,0.0002018248],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1800024,0.1148531,0.05270338,0.01189606,0.01196374,0.5279229,0.02181602,0.001480369,0.07736211],"genre_scores_gemma":[0.09836226,0.113278,0.06642772,0.006526981,0.002636868,0.5876004,0.01345133,0.0001432236,0.1115732],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02658422,"threshold_uncertainty_score":0.08893305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07673604775130666,"score_gpt":0.4640528874805306,"score_spread":0.3873168397292239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}