{"id":"W4386165007","doi":"10.1101/2023.08.24.554661","title":"Impaired aldehyde detoxification caused by a common human polymorphism promotes anti-bacterial immunity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; National Institutes of Health; National Medical Research Council; National Research Foundation Singapore; National Research Foundation; Medical Research Council; Canadian Institute for Advanced Research; Howard Hughes Medical Institute","keywords":"Francisella tularensis; ALDH2; Francisella; Biology; Microbiology; Mycobacterium tuberculosis; Aldehyde dehydrogenase; Immune system; Tuberculosis; Immunology; Medicine; Virulence; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001929571,0.0003145327,0.0002458936,0.0003111481,0.0001107134,0.0002970531,0.0001135445,0.0003322709,0.002991826],"category_scores_gemma":[0.0003046606,0.0001005537,0.0002159779,0.0002111488,0.00026735,0.0000881313,0.0002220481,0.0003347171,0.0002966424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000886742,"about_ca_system_score_gemma":0.00009514244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003999538,"about_ca_topic_score_gemma":0.0003122655,"domain_scores_codex":[0.9998467,0.00003824984,0.00001129819,0.00005730957,0.00002633982,0.00002009335],"domain_scores_gemma":[0.9998337,0.00003519264,0.00006309601,0.00002072981,0.00001319926,0.0000340445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003522435,0.0001425599,0.1374774,0.0001513977,0.0003358114,0.003332496,0.0001606383,0.0004395012,0.840224,0.0007899201,0.001412624,0.01201131],"study_design_scores_gemma":[0.0001795832,0.0009557321,0.7362269,0.0000406789,0.0005514796,0.01710758,0.0002512569,0.002841587,0.2301704,0.001770367,0.00986108,0.00004337532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975747,0.0003934966,0.001045936,0.0001542428,0.0000301021,0.000003732891,0.000301003,0.00004130573,0.0004555167],"genre_scores_gemma":[0.9988312,0.000109784,0.0003633595,0.00005608622,0.00003035266,0.000003188608,0.000157128,0.00001060805,0.0004382871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002991826,"threshold_uncertainty_score":0.01000863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01950750344938415,"score_gpt":0.2431276168631536,"score_spread":0.2236201134137694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}