{"id":"W4386168072","doi":"10.3390/pharmaceutics15092201","title":"Long-Term Survival and Induction of Operational Tolerance to Murine Islet Allografts by Co-Transplanting Cyclosporine A Microparticles and CTLA4-Ig","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research; Alberta Innovates; University of Alberta; Juvenile Diabetes Research Foundation United States of America","keywords":"Islet; Proinflammatory cytokine; FOXP3; Immunosuppression; Immune system; Cytotoxic T cell; Immunology; Chemokine; Transplantation; Medicine; PLGA; Chemistry; CD8; Pharmacology; Inflammation; Andrology; Endocrinology; Internal medicine; Diabetes mellitus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002012101,0.0001073682,0.0002068344,0.00007985657,0.00005982986,0.00001529947,0.00002679164,0.00003540432,0.00005679403],"category_scores_gemma":[0.00004025721,0.00009965642,0.00002031598,0.0001981216,0.0000694419,0.00006146514,0.00002276644,0.00009418101,0.00001145599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009590284,"about_ca_system_score_gemma":0.00001819013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001538812,"about_ca_topic_score_gemma":0.000002148379,"domain_scores_codex":[0.9992359,0.00002614878,0.0002109767,0.0001835545,0.0001645114,0.0001789089],"domain_scores_gemma":[0.9995978,0.00007550514,0.00003811512,0.00007807239,0.00005915078,0.0001513351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001255917,0.00005346994,0.3891658,0.0001633976,0.00004279519,0.000008839794,0.0001694097,0.00001435127,0.6079378,0.0000209305,0.0004885801,0.001808975],"study_design_scores_gemma":[0.002660093,0.0001185753,0.3776112,0.000113405,0.0001398757,0.00004651258,0.00007978624,0.00135375,0.6139899,0.00000775036,0.003738906,0.0001403228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973629,0.0004862302,0.00007788705,0.001394879,0.0001497985,0.0002219333,0.0000561061,0.0000590556,0.0001912192],"genre_scores_gemma":[0.9978738,0.0008271968,0.0002972434,0.0004661783,0.0001249788,0.0000107407,0.0001092894,0.00001336055,0.0002772486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01155471,"threshold_uncertainty_score":0.4063871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04784194452618692,"score_gpt":0.3478005330467369,"score_spread":0.29995858852055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}