{"id":"W4386168072","doi":"10.3390/pharmaceutics15092201","title":"Long-Term Survival and Induction of Operational Tolerance to Murine Islet Allografts by Co-Transplanting Cyclosporine A Microparticles and CTLA4-Ig","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Breakthrough T1D Canada; Canadian Institutes of Health Research; Alberta Innovates; University of Alberta; Juvenile Diabetes Research Foundation United States of America","keywords":"Islet; Proinflammatory cytokine; FOXP3; Immunosuppression; Immune system; Cytotoxic T cell; Immunology; Chemokine; Transplantation; Medicine; PLGA; Chemistry; CD8; Pharmacology; Inflammation; Andrology; Endocrinology; Internal medicine; Diabetes mellitus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000161519,0.0003869966,0.0002200683,0.0001837849,0.0001101361,0.000382132,0.0001945067,0.0002301714,0.0004006403],"category_scores_gemma":[0.0001020644,0.0001024146,0.0002331854,0.00009140548,0.0001843002,0.0002798404,0.0002317657,0.0005949385,0.0001898844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001703018,"about_ca_system_score_gemma":0.0002177125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001973325,"about_ca_topic_score_gemma":0.0002921609,"domain_scores_codex":[0.999846,0.00001500525,0.00001872644,0.00002762729,0.00003982292,0.00005288934],"domain_scores_gemma":[0.9997877,0.00002108579,0.00008057181,0.00002487482,0.00002087496,0.00006489154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000169264,0.00009480582,0.0002912396,0.0000203958,0.000004822094,0.0000413477,0.00001289736,0.00008156514,0.997237,0.00003899139,0.0000157318,0.001991825],"study_design_scores_gemma":[0.00002239363,0.001640827,0.003843458,0.000005912774,0.00002908596,0.0001729161,0.00002539278,0.0007413618,0.9927267,0.00002267497,0.0007651334,0.000004169947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974173,0.0006329135,0.001522885,0.0000244013,0.00002207781,0.00001010233,0.00004685793,0.00003604666,0.0002873505],"genre_scores_gemma":[0.9974552,0.0003706522,0.0009900571,0.00001724025,0.00001249884,0.00002158691,0.0001474987,0.00001211968,0.0009731478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004006403,"threshold_uncertainty_score":0.00134027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04784194452618692,"score_gpt":0.3478005330467369,"score_spread":0.29995858852055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}