{"id":"W4386169206","doi":"10.3233/jnd-230099","title":"Resistance Exercise Training Rescues Mitochondrial Dysfunction in Skeletal Muscle of Patients with Myotonic Dystrophy Type 1","year":2023,"lang":"en","type":"article","venue":"Journal of Neuromuscular Diseases","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Université du Québec à Chicoutimi","funders":"NIHR Newcastle Biomedical Research Centre; Fonds de Recherche du Québec - Santé; Université du Québec à Chicoutimi; Fondation du Grand défi Pierre Lavoie; Newcastle University; National Institute for Health and Care Research; Courtois Foundation; Wellcome Trust","keywords":"Myotonic dystrophy; Medicine; Skeletal muscle; Oxidative phosphorylation; Mitochondrial DNA; Internal medicine; Endurance training; Mitochondrion; Endocrinology; Cohort; Population; Cardiology; Biology; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008270054,0.0002272344,0.0004128592,0.0004597344,0.00008800086,0.00004492868,0.0003406122,0.00003912213,0.00003106436],"category_scores_gemma":[0.001251101,0.0001860933,0.0002238943,0.001182592,0.000162708,0.0003146805,0.00006100452,0.0001951762,0.000009042503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003501508,"about_ca_system_score_gemma":0.0002246345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001600086,"about_ca_topic_score_gemma":0.000004505074,"domain_scores_codex":[0.9973867,0.0003319411,0.0005913933,0.0003950017,0.0009621006,0.0003328928],"domain_scores_gemma":[0.9985372,0.0001801552,0.000468253,0.0003309596,0.0002759606,0.0002074151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005637411,0.002893229,0.07202468,0.0006057802,0.00008733157,0.001929712,0.001120831,0.0190533,0.884766,0.0001257092,0.002401098,0.009354955],"study_design_scores_gemma":[0.002997859,0.0009351561,0.9633633,0.0002945349,0.0001653252,0.000003791915,0.0001214279,0.00008061006,0.03061043,0.0001772498,0.0009956696,0.000254641],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984965,0.0002674889,0.00001757632,0.00007049814,0.0006779517,0.0003340816,0.00007581156,0.00003203836,0.0000281089],"genre_scores_gemma":[0.9993667,0.0002185741,0.0001103163,0.00005914774,0.000119358,0.00001158197,0.000008957154,0.00004585594,0.00005950212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8913386,"threshold_uncertainty_score":0.7588664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01984582286700864,"score_gpt":0.2391943622053731,"score_spread":0.2193485393383645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}