{"id":"W4386170848","doi":"10.1097/01.hs9.0000969780.55126.5b","title":"P719: RANDOMIZED PHASE 1-2 STUDY TO ASSESS SAFETY AND EFFICACY OF LOW-DOSE (LD) ORAL DECITABINE/CEDAZURIDINE (ASTX727) IN LOWER-RISK MYELODYSPLASTIC SYNDROMES (LR-MDS) PATIENTS: INTERIM SAFETY ANALYSIS","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; London Health Sciences Centre","funders":"","keywords":"Medicine; Decitabine; Internal medicine; Regimen; Myelodysplastic syndromes; Dosing; International Prognostic Scoring System; Adverse effect; Oncology; Gastroenterology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002616423,0.002672115,0.003077435,0.000590586,0.000611391,0.001576178,0.001219189,0.00209855,0.01136781],"category_scores_gemma":[0.001596456,0.001119036,0.001566126,0.0005999311,0.001464281,0.001632442,0.0005886862,0.004194126,0.002735346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0013769,"about_ca_system_score_gemma":0.002351426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006664876,"about_ca_topic_score_gemma":0.002375942,"domain_scores_codex":[0.999243,0.0003718846,0.00003258565,0.000142909,0.0000766997,0.0001328313],"domain_scores_gemma":[0.9990657,0.000156419,0.0002450554,0.00008791969,0.00006712137,0.000377738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9322003,0.02854181,0.001126684,0.0006359694,0.0007071277,0.0001208567,0.00006903043,0.0008137104,0.008835853,0.000221526,0.003029662,0.02369749],"study_design_scores_gemma":[0.8353817,0.1595824,0.001570214,0.00002494953,0.0002888602,0.0001027444,0.00002565676,0.0004819475,0.0007214518,0.0002879978,0.001506441,0.00002549012],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641128,0.003312572,0.002142371,0.001695368,0.0006109811,0.01840652,0.005314398,0.0004040438,0.004001129],"genre_scores_gemma":[0.9405162,0.003436141,0.005909207,0.004130251,0.0006403043,0.02320389,0.007719126,0.0001527262,0.01429221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01136781,"threshold_uncertainty_score":0.03802907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02923851966884173,"score_gpt":0.3558735861123752,"score_spread":0.3266350664435335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}