{"id":"W4386170848","doi":"10.1097/01.hs9.0000969780.55126.5b","title":"P719: RANDOMIZED PHASE 1-2 STUDY TO ASSESS SAFETY AND EFFICACY OF LOW-DOSE (LD) ORAL DECITABINE/CEDAZURIDINE (ASTX727) IN LOWER-RISK MYELODYSPLASTIC SYNDROMES (LR-MDS) PATIENTS: INTERIM SAFETY ANALYSIS","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; London Health Sciences Centre","funders":"","keywords":"Medicine; Decitabine; Internal medicine; Regimen; Myelodysplastic syndromes; Dosing; International Prognostic Scoring System; Adverse effect; Oncology; Gastroenterology; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002515257,0.0005458078,0.002858003,0.0009025712,0.0001168875,0.00005049332,0.0003562121,0.0001579442,0.001243235],"category_scores_gemma":[0.006220337,0.0004406259,0.0004605182,0.004628245,0.0002773358,0.0001770821,0.0005993018,0.000480266,0.000131447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002820723,"about_ca_system_score_gemma":0.001486067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244756,"about_ca_topic_score_gemma":0.0009070294,"domain_scores_codex":[0.994476,0.0007834965,0.001612537,0.001022869,0.001231786,0.0008733012],"domain_scores_gemma":[0.9942848,0.003320649,0.0003406789,0.001057621,0.0004116772,0.0005845694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8492634,0.02089456,0.06625139,0.002159534,0.01128151,0.003418713,0.008545564,0.009193239,0.0007981844,0.00009640757,0.00211204,0.02598544],"study_design_scores_gemma":[0.8660176,0.003223153,0.07536928,0.0008165643,0.002811506,0.00004001116,0.002692573,0.04793825,0.0002673278,0.00001688232,0.0002292094,0.0005776546],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940766,0.0001921656,0.0009668274,0.0001379354,0.0002195818,0.003738753,0.0001462078,0.0001311596,0.0003908096],"genre_scores_gemma":[0.9979581,0.0003035741,0.0003822627,0.00004459832,0.00005961475,0.0001362437,0.0002359232,0.00008616727,0.0007935269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03874501,"threshold_uncertainty_score":0.9998046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02923851966884173,"score_gpt":0.3558735861123752,"score_spread":0.3266350664435335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}