{"id":"W4386175017","doi":"10.1016/j.neo.2023.100929","title":"Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma","year":2023,"lang":"en","type":"article","venue":"Neoplasia","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Temozolomide; Methyltransferase; Cancer research; DNA methylation; O-6-methylguanine-DNA methyltransferase; Methylation; DNA methyltransferase; Biology; DNA repair; Glioma; DNA; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009837097,0.0001896413,0.0002736371,0.000141232,0.00008392542,0.0002364941,0.0001509387,0.0001768124,0.000728896],"category_scores_gemma":[0.0001011026,0.000081802,0.0001709808,0.00008045144,0.0001291317,0.00009881962,0.0001322778,0.0003900976,0.0001396993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002067926,"about_ca_system_score_gemma":0.0001817354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001405327,"about_ca_topic_score_gemma":0.002133759,"domain_scores_codex":[0.9999254,0.000009643733,0.000008697742,0.00001425056,0.00002183707,0.00002019389],"domain_scores_gemma":[0.9999682,0.000006153551,0.00000920774,0.000003610669,0.000004471602,0.000008356922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000596456,0.00002721942,0.0001226785,0.00002851945,0.000005075488,0.00002494883,0.00001152801,0.00008521574,0.9975852,0.00006165821,0.00004872131,0.001939555],"study_design_scores_gemma":[0.00001356937,0.0002950668,0.002313047,0.000004148213,0.0000190763,0.0001025778,0.00001159069,0.001304271,0.9939632,0.0000277937,0.001941616,0.000004087898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940327,0.001351657,0.003092658,0.00008325389,0.00003478285,0.00003515452,0.0002010528,0.0001327956,0.001035852],"genre_scores_gemma":[0.9964873,0.0007099801,0.001539351,0.00002966186,0.00000367153,0.00001660783,0.0002022471,0.00001490792,0.00099626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405327,"threshold_uncertainty_score":0.002794266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00973958906742449,"score_gpt":0.2637736408413736,"score_spread":0.2540340517739491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}