{"id":"W4386187769","doi":"10.1016/j.nucmedbio.2023.108383","title":"Comparison of three 18F-labeled 2-nitroimidazoles for imaging hypoxia in breast cancer xenografts: [18F]FBNA, [18F]FAZA and [18F]FMISO","year":2023,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Biodistribution; In vivo; Chemistry; Misonidazole; Hypoxia (environmental); In vitro; Imaging agent; Tumor hypoxia; Nitroimidazole; Breast cancer; Positron emission tomography; Cancer research; Pharmacology; Nuclear medicine; Cancer; Medicine; Radiation therapy; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001105991,0.0005958735,0.0007991167,0.0007564959,0.0005071266,0.0008236419,0.001053184,0.001257539,0.0008153726],"category_scores_gemma":[0.00117589,0.0006440587,0.0003814364,0.000527451,0.0005103591,0.0007823704,0.0002591051,0.0007746569,0.0002285949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001032558,"about_ca_system_score_gemma":0.0009273209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01072636,"about_ca_topic_score_gemma":0.01346453,"domain_scores_codex":[0.9995043,0.0001653189,0.00002932722,0.00009250904,0.0001013822,0.0001071636],"domain_scores_gemma":[0.9992393,0.0002899983,0.0001278666,0.00005177008,0.0001303515,0.0001607478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005188474,0.0001732461,0.001006606,0.0002629964,0.00008056347,0.00008308642,0.0001539241,0.0008377056,0.984825,0.0002323056,0.0001571709,0.006998928],"study_design_scores_gemma":[0.0002473158,0.003500798,0.005251448,0.00002339901,0.0002590409,0.0005435235,0.0001406771,0.004738708,0.9822311,0.00004412976,0.002970192,0.00004978088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797899,0.00905914,0.008250295,0.0002148847,0.00007666058,0.0001026435,0.0002996907,0.0001584222,0.002048448],"genre_scores_gemma":[0.9679049,0.005551399,0.02155726,0.0001239334,0.00003824275,0.0002539377,0.001020431,0.0001488987,0.003401059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01072636,"threshold_uncertainty_score":0.02132785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03751543908324462,"score_gpt":0.3402392192593726,"score_spread":0.3027237801761279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}