{"id":"W4386188628","doi":"10.1101/2023.08.24.554669","title":"Mouse model of multiple sclerosis induced by disrupting vesicular transport in oligodendrocytes","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; Systems, Applications & Products in Data Processing (Canada); Lunenfeld-Tanenbaum Research Institute; Ontario Brain Institute; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Multiple sclerosis; Myelin; Neuroinflammation; Neuroscience; Oligodendrocyte; Conditional gene knockout; Axon; Biology; Experimental autoimmune encephalomyelitis; Central nervous system; Inflammation; Immunology; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000526053,0.001186857,0.0007077439,0.00169178,0.000762104,0.0005744696,0.0006862637,0.00171783,0.005605407],"category_scores_gemma":[0.0001823558,0.0004591306,0.0007778943,0.000502258,0.0006603713,0.0005866513,0.0007069396,0.001614563,0.001810798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005499508,"about_ca_system_score_gemma":0.0003754624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000588041,"about_ca_topic_score_gemma":0.0009923002,"domain_scores_codex":[0.9995208,0.00005750371,0.00008890514,0.0001186673,0.0001280823,0.00008606527],"domain_scores_gemma":[0.9994867,0.0000590428,0.0001953834,0.00006264524,0.00004880175,0.0001472991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004029894,0.0002432069,0.0003408644,0.000137738,0.00003486542,0.0008952631,0.0000870482,0.00008515607,0.9939627,0.001311657,0.0005987091,0.001899818],"study_design_scores_gemma":[0.0002661134,0.00143117,0.003933106,0.00009307401,0.0001723233,0.003133717,0.0001069176,0.001784731,0.9705666,0.001078797,0.01739965,0.00003387646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571208,0.003374633,0.02143936,0.001848815,0.0007422705,0.0003719985,0.005129943,0.002630614,0.007341344],"genre_scores_gemma":[0.9207461,0.003192427,0.02363048,0.0006282533,0.0001580722,0.0009314728,0.004654629,0.0005037961,0.04555477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005605407,"threshold_uncertainty_score":0.01875192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07322357156450196,"score_gpt":0.2360232254666619,"score_spread":0.1627996539021599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}