{"id":"W4386191174","doi":"10.1101/2023.08.24.554410","title":"KCC2 as a novel biomarker and therapeutic target for motoneuron degenerative disease","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; McGill University; Occupational Cancer Research Centre; University of Toronto; Montreal Neurological Institute and Hospital; Université Laval","funders":"","keywords":"Amyotrophic lateral sclerosis; SOD1; Corticospinal tract; Spinal cord; Neuroscience; Motor neuron; GABAergic; Symporter; Medicine; Biology; Internal medicine; Disease; Inhibitory postsynaptic potential; Transporter; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003335973,0.0005748853,0.0008545592,0.0005700285,0.000204767,0.0007982068,0.0004587561,0.0008796393,0.001527574],"category_scores_gemma":[0.0001538268,0.0001175342,0.0002443008,0.0004779022,0.000276904,0.000315695,0.0002512213,0.0007855346,0.0005416067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008319145,"about_ca_system_score_gemma":0.0004732785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006623988,"about_ca_topic_score_gemma":0.001257553,"domain_scores_codex":[0.9998643,0.00002000314,0.00001117622,0.00003394477,0.0000417207,0.00002871332],"domain_scores_gemma":[0.9998778,0.00001028221,0.00003805044,0.000008679473,0.0000385653,0.00002661344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002569401,0.0004090288,0.00598306,0.001424544,0.000157341,0.0007805431,0.00005449313,0.000615532,0.9019943,0.001268647,0.003612582,0.0811305],"study_design_scores_gemma":[0.000954727,0.009747144,0.04533356,0.0006688686,0.001099101,0.006787674,0.0002527517,0.008076794,0.787502,0.00140384,0.1380503,0.0001232864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6686123,0.3008047,0.01038076,0.003223625,0.001072297,0.0006306443,0.002475228,0.0006679042,0.01213251],"genre_scores_gemma":[0.9476319,0.03795514,0.005736555,0.0008600772,0.0003226746,0.0003643176,0.001892832,0.00003973455,0.005196787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527574,"threshold_uncertainty_score":0.006035984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06095307086179539,"score_gpt":0.3001308056577266,"score_spread":0.2391777347959312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}