{"id":"W4386200290","doi":"10.1016/j.mehy.2023.111151","title":"Early maladaptive schemas and depression: Epigenetics as a possible link","year":2023,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"Child and Adolescent Psychosocial and Emotional Development","field":"Psychology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Epigenetics; Major depressive disorder; Psychology; Serotonin transporter; Mood disorders; Dysfunctional family; DNA methylation; Mood; Neuroscience; Clinical psychology; Psychiatry; Genetics; Biology; Gene; Gene expression; Genotype; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007297408,0.0002113204,0.0002059045,0.0004335848,0.0003201514,0.0009519908,0.0004749491,0.0007180247,0.003842336],"category_scores_gemma":[0.001968261,0.0002197605,0.0001776242,0.0003471088,0.001031266,0.0005863774,0.0003829437,0.0006720287,0.0001316138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003648842,"about_ca_system_score_gemma":0.0006056571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001401644,"about_ca_topic_score_gemma":0.00269612,"domain_scores_codex":[0.9997106,0.00009198274,0.0000119339,0.00009271072,0.00003857736,0.00005412231],"domain_scores_gemma":[0.999308,0.0003240556,0.0001705942,0.00006230447,0.00005412951,0.00008101923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0009796602,0.001327955,0.8396129,0.0003794433,0.0005599263,0.002550249,0.00430096,0.0006410177,0.03627156,0.04666321,0.001130254,0.06558283],"study_design_scores_gemma":[0.00005871806,0.0004740832,0.9638819,0.0002122175,0.0001660826,0.001215227,0.003188859,0.0007460552,0.005174683,0.01939279,0.005464179,0.0000253732],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707265,0.009537492,0.00270615,0.006421567,0.0001280108,0.00003757199,0.0004756863,0.00001825867,0.00994873],"genre_scores_gemma":[0.9917858,0.003790092,0.001274869,0.0005248673,0.00005864871,0.00002445458,0.0001709661,0.000004021461,0.002366242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003842336,"threshold_uncertainty_score":0.01285386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03568599628209908,"score_gpt":0.3075046990056384,"score_spread":0.2718187027235393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}