{"id":"W4386200561","doi":"10.1186/s12915-023-01683-2","title":"Differential functions of RhoGDIβ in malignant transformation and progression of urothelial cell following N-butyl-N-(4-hydmoxybutyl) nitrosamine exposure","year":2023,"lang":"en","type":"article","venue":"BMC Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; School of Medicine, New York University; Scientific Research Foundation of Education Department of Anhui Province of China; York University","keywords":"Biology; Nitrosamine; Cancer research; Cell; Transformation (genetics); Malignant transformation; Differential (mechanical device); Cell biology; Cell growth; Carcinogen; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101621,0.0001816821,0.0002039949,0.0002134341,0.0001347948,0.0001691728,0.0000920929,0.0001756298,0.0008299917],"category_scores_gemma":[0.00007523092,0.0001046108,0.000293712,0.0001438022,0.0001767126,0.0001496148,0.0001559088,0.0003271289,0.0001895874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001698721,"about_ca_system_score_gemma":0.0001450371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006034315,"about_ca_topic_score_gemma":0.0008156442,"domain_scores_codex":[0.9998982,0.00001672434,0.000008951422,0.00002262304,0.00002463035,0.00002880838],"domain_scores_gemma":[0.9999362,0.000006035374,0.00001913941,0.000008241122,0.00001290555,0.00001743395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001846665,0.0000190936,0.001277508,0.00003477897,0.000005014267,0.00006575337,0.00003381741,0.00002274607,0.9974722,0.00002382468,0.00002059931,0.0008399657],"study_design_scores_gemma":[0.000007641023,0.0005972879,0.06908587,0.000009464154,0.00002309721,0.0003835034,0.0001876065,0.0004623334,0.9273321,0.00005540257,0.001848787,0.000006911654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951972,0.002712915,0.0008656038,0.00006303022,0.00001667183,0.00001567496,0.0003090865,0.00003011812,0.0007895277],"genre_scores_gemma":[0.9967193,0.001000139,0.000581672,0.00002501763,0.000005350489,0.00003755458,0.0003861598,0.000005314839,0.001239493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008299917,"threshold_uncertainty_score":0.002776623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01258747506119333,"score_gpt":0.2606389466588839,"score_spread":0.2480514715976906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}