{"id":"W4386209368","doi":"10.1111/imm.13686","title":"Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis","year":2023,"lang":"en","type":"article","venue":"Immunology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fundação para a Ciência e a Tecnologia; Canada Research Chairs; Agence Nationale de la Recherche","keywords":"Leishmania donovani; Immune system; Biology; Visceral leishmaniasis; Immunology; Adipose tissue; Macrophage; Leishmania; Lipid metabolism; Cutaneous leishmaniasis; Microbiology; Leishmaniasis; In vitro; Parasite hosting; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004481947,0.0002601892,0.0005513444,0.0003558658,0.0003025823,0.00006189713,0.0001465296,0.0001462328,0.00008820702],"category_scores_gemma":[0.0003841917,0.0002017014,0.00007594736,0.0006010255,0.0004388821,0.0001405449,0.0001506277,0.0003577686,0.00008921125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001307108,"about_ca_system_score_gemma":0.0001325586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001270637,"about_ca_topic_score_gemma":0.00004954859,"domain_scores_codex":[0.9980339,0.000343054,0.0003061127,0.0004323329,0.0003054664,0.0005791672],"domain_scores_gemma":[0.9985244,0.0006311284,0.0001366663,0.0003725327,0.0002480483,0.00008721888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01518061,0.001098267,0.2653451,0.0001621395,0.003219521,0.001119921,0.01481133,0.00002413832,0.6010334,0.00005341976,0.0297168,0.06823529],"study_design_scores_gemma":[0.00720111,0.001293596,0.9511745,0.00009443154,0.00004721196,0.00003436071,0.000995871,0.0004769083,0.03521391,0.0000403049,0.003175154,0.0002526499],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915917,0.001659049,0.000004256675,0.004884649,0.0001100318,0.0006847192,0.00002931284,0.0003680566,0.0006682374],"genre_scores_gemma":[0.9914391,0.004230643,0.00008026082,0.0006151686,0.0000873723,0.00007945984,0.00007946339,0.00005531718,0.003333205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6858294,"threshold_uncertainty_score":0.8225143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04768041895020959,"score_gpt":0.3214404198208202,"score_spread":0.2737600008706106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}