{"id":"W4386209368","doi":"10.1111/imm.13686","title":"Intramacrophage lipid accumulation compromises T cell responses and is associated with impaired drug therapy against visceral leishmaniasis","year":2023,"lang":"en","type":"article","venue":"Immunology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fundação para a Ciência e a Tecnologia; Canada Research Chairs; Agence Nationale de la Recherche","keywords":"Leishmania donovani; Immune system; Biology; Visceral leishmaniasis; Immunology; Adipose tissue; Macrophage; Leishmania; Lipid metabolism; Cutaneous leishmaniasis; Microbiology; Leishmaniasis; In vitro; Parasite hosting; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150999,0.0002785717,0.0002927704,0.0002224859,0.0001030926,0.0002004421,0.0001003008,0.0002597074,0.001090242],"category_scores_gemma":[0.0001070422,0.0001015911,0.0001497253,0.0001068337,0.0001732852,0.0001197572,0.0001639362,0.0005429345,0.0001807297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001149926,"about_ca_system_score_gemma":0.00009094607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00012362,"about_ca_topic_score_gemma":0.0001647543,"domain_scores_codex":[0.9998879,0.00002974206,0.00001134102,0.00001743984,0.00002047257,0.00003299909],"domain_scores_gemma":[0.9998703,0.00001312126,0.00004918823,0.00001102031,0.00001211094,0.00004414279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001114625,0.0001858334,0.001058257,0.00005423095,0.00001203871,0.0001576629,0.00001313056,0.00004282651,0.9946625,0.00004025516,0.00005765663,0.002601047],"study_design_scores_gemma":[0.0002739552,0.0116687,0.04455787,0.00003099245,0.0001286531,0.002601707,0.0001176317,0.001642005,0.9330937,0.0001764505,0.005695328,0.00001302985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978961,0.000947489,0.0004688783,0.00006139514,0.00001957955,0.00001778734,0.00007634646,0.00003252609,0.0004798555],"genre_scores_gemma":[0.998463,0.0003016026,0.0002194883,0.00004703432,0.000008504061,0.00001889388,0.00010111,0.000005206997,0.0008350899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001090242,"threshold_uncertainty_score":0.003647149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04768041895020959,"score_gpt":0.3214404198208202,"score_spread":0.2737600008706106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}